ArticleOpen forum infectious diseases2026
BACT-URIE: A Novel Score Integrating Bacteriuria to Predict Infective Endocarditis in Patients With
Article in Open forum infectious diseases, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Infective endocarditis (IE) is a serious complication of Methods: We retrospectively analyzed 2 temporally distinct cohorts of adult SAB patients in a French tertiary hospital: a derivation cohort (2012-2019, n = 233) and a validation cohort (2020-2023, n = 156). Patients with proven urinary tract infection were excluded. Logistic regression identified predictors of IE, which were converted into weighted points to develop 2 scores: day 1 (baseline variables) and day 4 (including persistent bacteremia ≥72 hours). Performance was compared with VIRSTA and PREDICT. Results: Infective endocarditis occurred in 14.6% of the derivation cohort and 14.7% of the validation cohort. Independent predictors were intracardiac devices, community acquisition, bacteriuria, septic emboli, and persistent bacteremia. AUROCs for the day 1 and day 4 scores were 0.78 and 0.81 in derivation, and 0.91 and 0.93 in validation. At thresholds of >2 and >3, sensitivities were 67.65% and 70.59%, with negative predictive values of 93.29% and 93.83%, respectively. Compared with VIRSTA and PREDICT, BACT-URIE showed higher sensitivity in this cohort. Conclusions: BACT-URIE is an exploratory score incorporating
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