ArticleJournal of orthopaedic translation2026
RhoA deficiency in chondrocyte inhibits cartilage fibrosis and ameliorates osteoarthritis progression via SOX4/MMP2 axis.
Article in Journal of orthopaedic translation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
2 citing papers in PubMed.
- Artemotil Attenuates Fibrosis-Associated Chondrocyte Remodelling in Osteoarthritis in Association With STC1-Related TGF-β/SMAD2/3 Signalling.Journal of cellular and molecular medicine · 2026Article
- From local tissue repair to systemic precision orthopaedics: recent advances in musculoskeletal regeneration and translational medicine.Journal of orthopaedic translation · 2026Article
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Cartilage fibrosis plays a critical role in the onset and progression of osteoarthritis (OA), and although RhoA is a well-known small GTPase that regulates cytoskeletal reorganization, its role in OA progression remains inadequately explored. Methods: In this study, we first screened public scRNA-seq datasets for genes enriched in fibrocartilage chondrocytes and found that Results: The results showed that conditional knockout of Conclusion: These findings position The translational potential of this article: These findings highlight that RhoA may represent a therapeutic target for ameliorating cartilage fibrosis and the OA process via targeted gene intervention.
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