Evidence map›Paper›PMID 42205486›Full record

ArticleFrontiers in cellular and infection microbiology2026

Pathogenicity of

Karolina Strzelec, Agata Dziedzic-Kowalska, Klara Ferenc, Katarzyna Łazarz-Bartyzel, Iwona Olszewska-Czyż, Iwona Rąpalska, Łukasz Sieroń, Małgorzata Aptekorz, Małgorzata Romanik, Barbara Mendrek and 8 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in cellular and infection microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. International journal of molecular sciences · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Karolina StrzelecDepartment of Medical Microbiology, Faculty of Medical Sciences in Katowice, Medical University of Silesia, Katowice, Poland.
Agata Dziedzic-KowalskaDepartment of Molecular Biology, Faculty of Medical Sciences in Katowice, Medical University of Silesia, Katowice, Poland.
Klara FerencDepartment of Medical Microbiology, Faculty of Medical Sciences in Katowice, Medical University of Silesia, Katowice, Poland.
Katarzyna Łazarz-BartyzelDepartment of Periodontology, Preventive Dentistry and Oral Pathology, Faculty of Medicine, Medical College, Jagiellonian University, Krakow, Poland.
Iwona Olszewska-CzyżDepartment of Periodontology, Preventive Dentistry and Oral Pathology, Faculty of Medicine, Medical College, Jagiellonian University, Krakow, Poland.
Iwona RąpalskaDepartment of Oral Surgery, Faculty of Medicine, Medical College, Jagiellonian University, Krakow, Poland.
Łukasz SierońDepartment of Molecular Biology, Faculty of Medical Sciences in Katowice, Medical University of Silesia, Katowice, Poland.
Małgorzata AptekorzDepartment of Medical Microbiology, Faculty of Medical Sciences in Katowice, Medical University of Silesia, Katowice, Poland.
Małgorzata RomanikDepartment of Medical Microbiology, Faculty of Medical Sciences in Katowice, Medical University of Silesia, Katowice, Poland.
Barbara MendrekCentre of Polymer and Carbon Materials, Polish Academy of Sciences, Zabrze, Poland.
Natalia Oleszko-TorbusCentre of Polymer and Carbon Materials, Polish Academy of Sciences, Zabrze, Poland.
Agnieszka KowalczukCentre of Polymer and Carbon Materials, Polish Academy of Sciences, Zabrze, Poland.
Damian KuszDepartment of Orthopedics and Traumatology, Faculty of Medical Sciences in Katowice, Medical University of Silesia, Katowice, Poland.
Tomasz KaczmarzykDepartment of Oral Surgery, Faculty of Medicine, Medical College, Jagiellonian University, Krakow, Poland.
Marta Cześnikiewicz-GuzikDepartment of Periodontology, Preventive Dentistry and Oral Pathology, Faculty of Medicine, Medical College, Jagiellonian University, Krakow, Poland.
Paweł NiemiecDepartment of Biochemistry and Medical Genetics, Faculty of Health Sciences in Katowice, Medical University of Silesia, Katowice, Poland.
Tomasz J WasikDepartment of Medical Microbiology, Faculty of Medical Sciences in Katowice, Medical University of Silesia, Katowice, Poland.
Katarzyna GawronDepartment of Medical Microbiology, Faculty of Medical Sciences in Katowice, Medical University of Silesia, Katowice, Poland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Periodontitis (PD) is one of the most prevalent human inflammatory diseases of bacterial etiology, affecting over 50% of adult population worldwide. It is initiated by bacterial dysbiosis and bacteria-elicited inflammation. Among key periopathogens, the anaerobic bacterium, Methods: Clinical isolates from gingival crevicular fluid (GCF) of 35 PD patients and 20 healthy donors were analyzed for the presence, sequence variability, expression, and enzymatic activity of the ppad gene in Results: The Discussion: Collectively, these findings underscore that clusters of specific polymorphic variants of ppad are critical determinants of enzymatic function, host immune modulation and periodontal tissue destruction in PD.

Indexed as

Polymorphism, GeneticPorphyromonas gingivalisProtein-Arginine DeiminasesAnimalsBacteroidaceae InfectionsCell LineCytokinesFibroblastsGingival Crevicular FluidHost-Pathogen InteractionsHumansHydrolasesMiceOsteoblastsPeriodontitisVirulenceCytokinesHydrolasesProtein-Arginine Deiminasesclusterpathogenicitypeptidylarginine deiminaseperiodontitisP. gingivalispolymorphic variantsvirulence factors

Identifiers

PMID42205486
PMCPMC13201384

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.