Evidence map›Paper›PMID 42205440›Full record

ArticleFrontiers in public health2026

Molecular and serologic analysis of linked blood donor and recipient samples to rule out transfusion-transmitted parvovirus B19 infection.

Maureen J Miller, Maria Luisa Virata, Hailing Yan, Lilin Zhong, Sreya Tarafdar, Sarah Fowler, Pei Zhang, Harvey J Alter, Valeria De Giorgi

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In one paragraph

Article in Frontiers in public health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Maureen J MillerDepartment of Transfusion Medicine, National Institutes of Health Clinical Center, Bethesda, MD, United States.
Maria Luisa VirataPlasma Derivatives Branch 2, Division of Plasma Derivatives, Office of Plasma Protein Therapeutics, Office of Therapeutic Proteins, Center for Biologics Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, MD, United States.
Hailing YanPlasma Derivatives Branch 2, Division of Plasma Derivatives, Office of Plasma Protein Therapeutics, Office of Therapeutic Proteins, Center for Biologics Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, MD, United States.
Lilin ZhongPlasma Derivatives Branch 2, Division of Plasma Derivatives, Office of Plasma Protein Therapeutics, Office of Therapeutic Proteins, Center for Biologics Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, MD, United States.
Sreya TarafdarPlasma Derivatives Branch 2, Division of Plasma Derivatives, Office of Plasma Protein Therapeutics, Office of Therapeutic Proteins, Center for Biologics Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, MD, United States.
Sarah FowlerDepartment of Transfusion Medicine, National Institutes of Health Clinical Center, Bethesda, MD, United States.
Pei ZhangPlasma Derivatives Branch 2, Division of Plasma Derivatives, Office of Plasma Protein Therapeutics, Office of Therapeutic Proteins, Center for Biologics Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, MD, United States.
Harvey J AlterDepartment of Transfusion Medicine, National Institutes of Health Clinical Center, Bethesda, MD, United States.
Valeria De GiorgiDepartment of Transfusion Medicine, National Institutes of Health Clinical Center, Bethesda, MD, United States.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Parvovirus B19 (B19V) has been found in asymptomatic blood donors. This prospective study tested linked blood donor-recipient samples from patients transfused at the National Institutes of Health (NIH) and affiliated hospitals for the presence of B19V DNA and anti-B19 immunoglobulin G (IgG) antibodies to assess the risk of B19V transmission by transfusion. Materials and methods: Post-transfusion recipient plasma samples collected during 2002-2020 were tested for B19V DNA at 1, 2, 4, and/or 8 weeks by nested polymerase chain reaction (PCR), and for anti-B19 IgG at 12 and ≥24 weeks by enzyme immunoassay (EIA). To confirm B19V DNA-positive recipients, pre-transfusion and linked donation samples were tested for B19V DNA, anti-B19 IgG, and/or IgM. Tested samples included 1,352 subjects tested for DNA and anti-B19V IgG, or both. Results: No new transfusion-transmitted B19V infections were identified. Only one confirmed transfusion-transmitted infection (TTI) was identified overall. A total of 19 of 1,314 subjects tested for B19V DNA (1.4%, 95% confidence interval [CI]: 0.014 [0.009, 0.021]) had a positive result in their post-transfusion sample. A total of 876 of 1,290 tested subjects were positive for anti-B19V IgG antibody (68%, 95% CI: 0.679 [0.65, 0.70]). Antibody detection fluctuated among some recipients from 12 to 24 weeks. Discussion: The B19V DNA-positive rate in recipients was very low. All B19V DNA-positive recipients had pre-existing antibodies, indicating prior exposure. Although these data may not provide enough evidence to consider revising current B19V testing strategies, other pooled plasma testing data from around the world suggest that more widespread B19V monitoring of blood products could be indicated to prevent B19V infection in immunosuppressed or otherwise susceptible recipients (e.g., individuals with chronic hematological diseases, pregnant women less than 20 weeks gestation).

Indexed as

Blood DonorsParvoviridae InfectionsParvovirus B19, HumanTransfusion ReactionAdultAntibodies, ViralDNA, ViralFemaleHumansImmunoglobulin GMaleMiddle AgedPolymerase Chain ReactionProspective StudiesAntibodies, ViralDNA, ViralImmunoglobulin GB19blood donorsemerging infectious diseasesparvoviral infectionparvovirustransfusion-transmitted infections

Identifiers

PMID42205440
PMCPMC13201414

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.