ArticleSage open pediatrics
Neonatal Cholestasis Presenting With Seizures Associated With Vitamin K Deficiency: A Case Report.
Article in Sage open pediatrics. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Neonatal Cholestasis is one of the rare yet important causes of Vitamin K deficiency bleeding (VKDB) in infants. VKDB may present as Gastro Intestinal (GI) bleeding and in severe cases as Intracranial hemorrhage. We report a case of a 42 days old, previously healthy, male infant presenting with seizures and GI bleeding. Laboratory investigations revealed direct hyperbilirubinemia and markedly elevated PT/INR. These findings were consistent with neonatal cholestasis and Vitamin K deficiency. Cranial and Abdominal Ultrasonography were normal. The seizure was managed with Vit K and Fresh Frozen Plasma following which his coagulation profile and clinical status improved. Although intracranial hemorrhage could not be confirmed radiologically, this case highlights the importance of considering vitamin K deficiency and underlying hepatobiliary pathology in infants presenting with bleeding manifestations and seizures. Early recognition and treatment are essential to prevent life-threatening complications.
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