ArticleRSC advances2026
A QbD optimization of a pH-responsive Eudragit S100-chitosan nanoformulation for the co-delivery of pentoxifylline and simvastatin in colorectal cancer therapy.
Article in RSC advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Colorectal cancer (CRC) presents a significant global health challenge, where the efficacy of conventional treatments is often hampered by systemic toxicity, poor bioavailability, and drug resistance. Drug repurposing and nanotechnology offer promising avenues to overcome these limitations. While pH-responsive Eudragit S100-chitosan hybrid systems are established as robust pH-responsive oral delivery carriers, the present study introduces a novel therapeutic strategy by combining these platforms with the co-delivery of the repurposed drugs pentoxifylline (PTX) and simvastatin (SIM) for synergistic CRC therapy. A hybrid nanoparticle system was synthesized using ionic gelation, combining the mucoadhesive properties of chitosan with the pH-dependent release of Eudragit S100. The formulation was optimized using a Quality by Design (QbD) Box-Behnken design to yield nanoparticles with a particle size of 152 ± 5 nm, a zeta potential of +31.2 ± 1.5 mV, and high entrapment efficiency for both drugs (PTX: 85.4 ± 3.1%; SIM: 78.9 ± 2.8%).
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