ArticleFrontiers in endocrinology2026
Association between single-point insulin sensitivity estimator and three-vessel coronary disease: a cross-sectional study.
Article in Frontiers in endocrinology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: The single-point insulin sensitivity estimator (SPISE) is a novel surrogate marker for assessing insulin resistance in humans. Three-vessel coronary disease (TVD) remains a major challenge in coronary interventional therapy. However, the association between the SPISE index and TVD remains unclear. Therefore, this study aimed to evaluate the relationship between SPISE and TVD in an elderly population. Methods: Generalized additive models (GAM) and random forest variable importance scores were applied for feature selection to identify key predictors for constructing a TVD risk model. Multivariable regression and restricted cubic spline (RCS) analyses were performed to investigate the association between SPISE and TVD. Subgroup analyses were further conducted to assess potential effect modification. Results: GAM and random forest variable importance scores identified age and SPISE as the most important predictors. After adjustment for all covariates, SPISE was inversely associated with TVD (OR = 0.75, 95% CI: 0.68-0.83, Conclusion: A higher SPISE index is independently and inversely associated with TVD and may serve as a reliable predictor of disease risk, highlighting its potential utility in cardiovascular risk assessment.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.