Evidence map›Paper›PMID 42205194›Full record

ArticleMaterials today. Bio2026

A sequential and synergistic release sacrificial microgels scaffold for endometrial niche reprogramming and fertility restoration.

Qian Liu, Shun Lu, Junhua Zhou, Jie Xu, Jiaqin Shao, Jianqiong Zheng, Yinhe Zhang, Anqi Ye, Shuhong Tian, Chuanqi Qiu and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Materials today. Bio, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Qian LiuDepartment of Wound Healing, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, 325035, China.
Shun LuDepartment of Obstetrics and Gynecology, The First Affiliated Hospital of Ningbo University, Ningbo, Zhejiang, 315020, China.
Junhua ZhouSchool of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang, 325035, China.
Jie XuOujiang Laboratory (Zhejiang Lab for Regenerative Medicine, Vision and Brain Health), School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang, 325035, China.
Jiaqin ShaoSchool of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang, 325035, China.
Jianqiong ZhengDepartment of Obstetrics and Gynecology, The Third Clinical Institute Affiliated to Wenzhou Medical University, Wenzhou People's Hospital, Wenzhou Maternal and Child Health Care Hospital, Wenzhou, Zhejiang, 325035, China.
Yinhe ZhangSchool of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang, 325035, China.
Anqi YeOujiang Laboratory (Zhejiang Lab for Regenerative Medicine, Vision and Brain Health), School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang, 325035, China.
Shuhong TianHainan Pharmaceutical Research and Development Science Park, Hainan Medical University, Haikou, 571199, China.
Chuanqi QiuDepartment of Wound Healing, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, 325035, China.
Mengqi JinSchool of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang, 325035, China.
Maolin QinSchool of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang, 325035, China.
Zichang WuSchool of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang, 325035, China.
Somy YoonCollege of Pharmacy, Chonnam National University, Gwangju, 61186, South Korea.
Ling XieSchool of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang, 325035, China.
Lei ChenDepartment of Wound Healing, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, 325035, China.
Jian XiaoDepartment of Wound Healing, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, 325035, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Intrauterine adhesions (IUA) remain a therapeutic challenge, necessitating advanced regenerative strategies. Herein, we propose a "programmed endometrial niche" strategy, a 3D-printed adipose-derived stem cells (ADSCs) hydrogel scaffold is constructed via microfluidic technology, incorporating platelet-rich plasma (PRP)-loaded thermosensitive gelatin microgels (PMS@AH) for sequential and synergistic delivery of PRP and ADSCs to restore the endometrial immune microenvironment and niche. In vitro assays demonstrate that PMS@AH possesses excellent biocompatibility and significantly promoted cell proliferation, migration, and angiogenesis, accompanied by potent anti-inflammatory activity. In both rat and cynomolgus macaque IUA models, it effectively restored endometrial structure, reduced fibrosis and inflammation, and successfully restored fertility. Mechanistically, RNA-sequencing analysis reveals that PMS@AH involves suppressing the IL-17/nuclear factor-κB (NF-κB) pathway to modulate the immune microenvironment and inhibiting the Wnt/β-catenin pathway to program the endometrial niche. This sequentially releasing scaffold presents a promising platform for treating IUA and broader applications in reproductive medicine.

Indexed as

3D printingAdipose-derived stem cellsEndometrial nicheFertilityHydrogel scaffoldsPlatelet-rich plasma

Identifiers

PMID42205194
PMCPMC13202539

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.