ArticleFrontiers in surgery2026
Impact of severe thrombocytopenia on the safety of splenectomy in patients with cirrhosis predominantly caused by Wilson's disease.
Article in Frontiers in surgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Abstract
Objective: Due to the risk of bleeding and other related complications, severe thrombocytopenia (PLT ≤ 30 × 10 Methods: Patients were divided into three groups according to preoperative platelet count: mild, moderate, and severe thrombocytopenia. Baseline characteristics, surgical variables, postoperative outcomes, complications, and dynamic perioperative platelet counts were collected for all patients. Statistical analysis was performed using SPSS 27.0 to compare the differences in clinical data among the three groups. Results: No significant differences were observed among the three groups in baseline data, surgical indicators, mortality, gastric tube drainage volume, or total drainage volume ( Conclusion: In Child-Pugh A/B patients with cirrhosis predominantly caused by Wilson's disease and hypersplenism, severe preoperative thrombocytopenia is not an absolute contraindication to splenectomy. Liver functional reserve is critical for surgical safety. However, severe thrombocytopenia is associated with an increased risk of PVT, which necessitates intensified perioperative anticoagulation.
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