Evidence map›Paper›PMID 42205161›Full record

ArticleBrain communications2026

Brain-specific immune hub activation in paediatric focal lesional epilepsy: a case-control study.

Antonio G Gennari, Alexia Rossi, Thomas Sartoretti, Moritz Schwyzer, Dorottya Cserpan, Valerie Treyer, Martin W Huellner, Ruth O'Gorman Tuura, Georgia Ramantani, Michael Messerli

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In one paragraph

Article in Brain communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Antonio G GennariDepartment of Nuclear Medicine, University Hospital Zurich, 8091 Zurich, Switzerland.ORCID https://orcid.org/0000-0003-2224-0083
Alexia RossiDepartment of Nuclear Medicine, University Hospital Zurich, 8091 Zurich, Switzerland.ORCID https://orcid.org/0000-0001-6845-1199
Thomas SartorettiDepartment of Nuclear Medicine, University Hospital Zurich, 8091 Zurich, Switzerland.ORCID https://orcid.org/0000-0002-4812-987X
Moritz SchwyzerDepartment of Nuclear Medicine, University Hospital Zurich, 8091 Zurich, Switzerland.ORCID https://orcid.org/0000-0002-9095-032X
Dorottya CserpanDepartment of Neuropediatrics, University Children's Hospital of Zurich, 8008 Zurich, Switzerland.ORCID https://orcid.org/0000-0002-7538-1931
Valerie TreyerDepartment of Nuclear Medicine, University Hospital Zurich, 8091 Zurich, Switzerland.ORCID https://orcid.org/0000-0002-4584-3031
Martin W HuellnerDepartment of Nuclear Medicine, University Hospital Zurich, 8091 Zurich, Switzerland.ORCID https://orcid.org/0000-0002-4849-3292
Ruth O'Gorman TuuraUniversity of Zurich, 8006 Zurich, Switzerland.ORCID https://orcid.org/0000-0001-5932-7786
Georgia RamantaniUniversity of Zurich, 8006 Zurich, Switzerland.ORCID https://orcid.org/0000-0002-7931-2327
Michael MesserliDepartment of Nuclear Medicine, University Hospital Zurich, 8091 Zurich, Switzerland.ORCID https://orcid.org/0000-0001-7815-3048

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

There are still some gaps in understanding the role of inflammation in focal lesional epilepsy. Surgical specimens often contain activated leukocytes, usually thought to originate from the systemic circulation. However, the cerebrospinal fluid, meninges, and skull form a distinct brain-specific immune hub that also reacts to local signals. This study assessed immune hub activation adjacent to epileptogenic lesions in children with focal lesional epilepsy using 2-[

Indexed as

brain-specific immune hubFDG-PETinflammationmetabolic activitypaediatric epilepsy

Identifiers

PMID42205161
PMCPMC13201093

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.