Trial reportBrain and behavior2026
Role of Contralesional Corticoreticulospinal Tract Compensation in Walking Function After Stroke.
Trial report in Brain and behavior, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02858349 (Mechanisms of Walking Recovery After Stroke), which is not on this map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Mechanisms of Walking Recovery After Stroke
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3 authors.
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Abstract
introductionEvidence suggests the contralesional corticoreticulospinal tract (cCRST) upregulates after stroke and that this upregulation correlates with worse motor function, suggesting it may be harmful for walking function. However, this relationship may be confounded by the extent of ipsilesional corticospinal tract (CST) and CRST damage, which could cause both greater cCRST upregulation and worse walking function. No previous studies have tested whether this confounding relationship exists, nor whether the amount of damage to the ipsilesional motor tracts is related to the amount of cCRST upregulation. We hypothesized that lower ipsilesional motor tract strength would (1) be associated with greater cCRST strength and (2) explain the observed association between cCRST strength and walking function.
methodsTen individuals with chronic stroke and 10 age- and sex-matched controls completed diffusion MRI, from which quantitative anisotropy was derived to evaluate the strength of the ipsilesional and contralesional CRST and CST. Walking capacity was assessed using 6-min walk distance (6MWD). Linear regressions were applied to examine relationships among ipsilesional corticomotor tract strength (iCRST and iCST combined), cCRST strength, and 6MWD.
resultsCompared with controls, participants with stroke had lower ipsilesional and higher contralesional strength for both motor tracts. Lower ipsilesional tract strength was associated with greater cCRST strength z-score (-0.12 SDs [-0.23, -0.02]). The unadjusted association between greater cCRST strength z-score and lower walking capacity (-72 m [-136, -9]) was no longer present after adjusting for ipsilesional tract strength (-3 m [-28, 23]).
conclusionsGreater damage to ipsilesional motor tracts (lower strength) was associated with increased cCRST strength. The extent of ipsilesional tract injury fully explained the negative association between cCRST strength and worse walking capacity. These findings suggest that cCRST upregulation may be an adaptive compensation; however, larger studies are needed to better understand the impact of cCRST upregulation on walking function.
trial registrationClinicalTrials.gov identifier: NCT02858349.
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