Evidence map›Paper›PMID 42204756›Full record

ArticleJournal of cellular and molecular medicine2026

Myeloid Cell Function and Cytokine Profiles in Paediatric Haemophilia A: Insights From FVIII and Emicizumab Prophylaxis.

Alessia Cottonaro, Saicharan Akula, Berardino Pollio, Irene Ricca, Tiziano Martini, Roberto Albiani, Jacopo Agnelli Giacchello, Patrizia Sciancalepore, Roberto Santi, Antonia Follenzi and 1 more

Abstract read
In one paragraph

Article in Journal of cellular and molecular medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Alessia CottonaroHealth Sciences, Università del Piemonte Orientale, Novara, Italy.
Saicharan AkulaHealth Sciences, Università del Piemonte Orientale, Novara, Italy.
Berardino PollioDiagnostic Department, A.O. Città Della Salute e Della Scienza, SIMT Immunohematology and Transfusion Medicine Service, Torino, Italy.ORCID 0000-0002-7981-7165
Irene RiccaDiagnostic Department, A.O. Città Della Salute e Della Scienza, SIMT Immunohematology and Transfusion Medicine Service, Torino, Italy.
Tiziano MartiniDiagnostic Department, A.O. Città Della Salute e Della Scienza, SIMT Immunohematology and Transfusion Medicine Service, Torino, Italy.
Roberto AlbianiDiagnostic Department, A.O. Città Della Salute e Della Scienza, SIMT Immunohematology and Transfusion Medicine Service, Torino, Italy.
Jacopo Agnelli GiacchelloAzienda Ospedaliera SS. Antonio e Biagio e Cesare Arrigo, Alessandria, Italy.
Patrizia SciancaleporeAzienda Ospedaliera SS. Antonio e Biagio e Cesare Arrigo, Alessandria, Italy.
Roberto SantiAzienda Ospedaliera SS. Antonio e Biagio e Cesare Arrigo, Alessandria, Italy.
Antonia FollenziHealth Sciences, Università del Piemonte Orientale, Novara, Italy.
Simone MerlinHealth Sciences, Università del Piemonte Orientale, Novara, Italy.ORCID 0000-0001-5209-3921

Funding

GrifolsMinistero dell'Università e della RicercaRoche ItaliaUniversità degli Studi del Piemonte Orientale
6 · The paper itself

Abstract

Haemophilia A (HA) is an X-linked bleeding disorder caused by factor VIII (FVIII) deficiency, treated with FVIII infusions or, more recently, Emicizumab subcutaneously. Although Emicizumab is safe and effective, FVIII is still required for severe bleeding, trauma, or surgery, and few studies have compared these prophylactic options in paediatric patients. This study explores the immunological and haematological profiles of paediatric HA patients receiving FVIII or Emicizumab, using haemophilia B patients and healthy controls. Clinical parameters and immune cell populations showed no major differences aside from age-related variations. However, HA patients displayed higher HLA-DR expression on CD14

Indexed as

Antibodies, BispecificAntibodies, Monoclonal, HumanizedCytokinesFactor VIIIHemophilia AMyeloid CellsAdolescentChildChild, PreschoolFemaleHumansInfantMacrophagesMaleAntibodies, BispecificAntibodies, Monoclonal, HumanizedCytokinesemicizumabFactor VIIIHA prophylaxismyeloid cellspaediatric patients

Identifiers

PMID42204756
PMCPMC13240037

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.