Evidence map›Paper›PMID 42204718›Full record

ReviewBMC biology2026

Mitochondria-ER contact sites (MERCS) in the cell cycle: molecular architecture and functional remodeling across cellular states.

Eduardo Silva-Pavez, Bruno Torres-Gonzalez, Michelle Sotomayor, Benjamín Cartes-Saavedra, Dorian V Ziegler, Yessia Hidalgo-Fadic, Ulises Ahumada-Castro

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in BMC biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Eduardo Silva-PavezFacultad de Odontología, Universidad San Sebastián, Bellavista 7, Recoleta, Santiago, Chile.
Bruno Torres-GonzalezIMPACT, Center of Interventional Medicine for Precision and Advanced Cellular Therapy, Universidad de los Andes, Monseñor Álvaro del Portillo 12.455, Las Condes, Santiago, Chile.
Michelle SotomayorIMPACT, Center of Interventional Medicine for Precision and Advanced Cellular Therapy, Universidad de los Andes, Monseñor Álvaro del Portillo 12.455, Las Condes, Santiago, Chile.
Benjamín Cartes-SaavedraMitoCare Center for Mitochondrial Imaging Research and Diagnostics, Department of Pathology and Genomic Medicine, Thomas Jefferson University, Philadelphia, PA, USA.
Dorian V ZieglerCenter for Integrative Genomics, Faculty of Biology and Medicine, University of Lausanne, Lausanne, Switzerland.
Yessia Hidalgo-FadicIMPACT, Center of Interventional Medicine for Precision and Advanced Cellular Therapy, Universidad de los Andes, Monseñor Álvaro del Portillo 12.455, Las Condes, Santiago, Chile. yhidalgo@uandes.cl.
Ulises Ahumada-CastroFacultad de Odontología, Universidad San Sebastián, Bellavista 7, Recoleta, Santiago, Chile. ulises.ahumada@uss.cl.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mitochondria-endoplasmic reticulum (ER) contact sites (MERCS) are nanoscopic, dynamic platforms integrating metabolism, signaling, and stress responses to regulate cell fate. These nanoscopic interfaces remodel continuously to meet the demands of proliferating, quiescent, and senescent cells. We synthesize evidence that MERCS actively coordinate local Ca

Indexed as

Cell CycleEndoplasmic ReticulumMitochondriaAnimalsCellular SenescenceHumansMitochondria Associated MembranesCalcium signalingCell-cycle regulationCellular senescenceLipid transferMitochondria–ER contact sites

Identifiers

PMID42204718
PMCPMC13397733

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.