ArticlePest management science2026
Structure guided development of phenoxyethanol based N-aryloxyethyl heterocycles for the control of Phytophthora infestans.
Article in Pest management science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundLate blight caused by the oomycete Phytophthora infestans remains one of the most devastating diseases threatening global potato and tomato production. Overuse of a narrow range of fungicides has sped up resistance, making it urgent to develop new agents that work differently and are safer.
resultsIn this study, a series of N-aryloxyethyl heterocycles were rationally designed by integrating the aryloxyethyl scaffold of phenoxyethanol with bioactive heterocyclic frameworks. Among the 40 synthesized derivatives, compound 8c exhibited the highest anti-oomycete activity against P. infestans, with an EC
conclusionCollectively, these results identify compound 8c as a promising anti-oomycete lead that combines high efficacy, multi-level metabolic disruption, and encouraging safety characteristics for late blight management. © 2026 Society of Chemical Industry.
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