Evidence map›Paper›PMID 42204616›Full record

ArticleAlzheimer's research & therapy2026

Seven tesla MRI reveals amygdala and hippocampal subfield atrophy in dementia with Lewy bodies.

Elizabeth McKiernan, Peter Swann, Elijah Mak, Maria Prats-Sedano, George Savulich, Allison Bentley, Guy Williams, Li Su, John T O'Brien

Abstract read
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Article in Alzheimer's research & therapy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Elizabeth McKiernanDepartment of Psychiatry, University of Cambridge, Cambridge Biomedical Campus, Cambridge, CB2 0SL, UK. em654@medschl.cam.ac.uk.
Peter SwannDepartment of Psychiatry, University of Cambridge, Cambridge Biomedical Campus, Cambridge, CB2 0SL, UK.
Elijah MakDepartment of Psychiatry, University of Cambridge, Cambridge Biomedical Campus, Cambridge, CB2 0SL, UK.
Maria Prats-SedanoDepartment of Psychiatry, University of Cambridge, Cambridge Biomedical Campus, Cambridge, CB2 0SL, UK.
George SavulichDepartment of Psychiatry, University of Cambridge, Cambridge Biomedical Campus, Cambridge, CB2 0SL, UK.
Allison BentleyDepartment of Psychiatry, University of Cambridge, Cambridge Biomedical Campus, Cambridge, CB2 0SL, UK.
Guy WilliamsWolfson Brain Imaging Centre, University of Cambridge, Cambridge Biomedical Campus, Cambridge, CB2 0SL, UK.
Li SuDepartment of Psychiatry, University of Cambridge, Cambridge Biomedical Campus, Cambridge, CB2 0SL, UK.
John T O'BrienDepartment of Psychiatry, University of Cambridge, Cambridge Biomedical Campus, Cambridge, CB2 0SL, UK.

Funding

Alzheimer's Research UK ARUK-SRF2017B-1Alzheimer's Society AS-CTF-17b-003Alzheimer's Society RG 9611Dementias Platform UK MR/T033371/1Lewy Body Society LB002/209NIHR Cambridge Biomedical Research Centre BRC-1215-20014
6 · The paper itself

Abstract

The 7T-DLB study investigated whether atrophy of individual hippocampal and amygdala subfields is present in dementia with Lewy bodies (DLB) as well as in Alzheimer's disease (AD) in which it has previously been established. MRI at standard clinical and research field strengths may have insufficient resolution to reveal the presence of atrophy in these regions in DLB; seven tesla MRI is ideally placed to examine subtle volumetric differences in these brain areas due to increased signal to noise ratio and tissue contrast.In this prospective, cross-sectional, seven tesla imaging study, 20 participants with probable DLB underwent MRI, clinical assessment, and cognitive testing, alongside a patient comparison group of 25 participants with probable AD, and 19 healthy controls. Scans were segmented using FreeSurfer automated pipelines. Hippocampal and amygdala subfield volumes were compared between diagnostic groups using a generalised linear model with age, sex, education, and total intracranial volume as covariates. Associations between volumes and cognition were examined using Kendall's tau. Exploratory analyses investigated associations between subfield volumes and visual hallucinations scores, and in a sub-set of 41 participants (DLB = 13, AD = 17, controls = 11), with plasma ptau-217 concentrations.Four (of 13) hippocampal subfields (molecular layer, subiculum, presubiculum, and entorhinal cortex) and five (of nine) amygdala subfields (accessory basal, central, medial and cortical nuclei, and anterior amygdaloid area) were significantly smaller in DLB compared to controls (p

Indexed as

AmygdalaHippocampusLewy Body DiseaseMagnetic Resonance ImagingAgedAged, 80 and overAlzheimer DiseaseAtrophyCross-Sectional StudiesFemaleHumansMaleNeuropsychological TestsProspective StudiesAlzheimer’s diseaseAmygdalaDementia with Lewy bodiesHippocampusSeven tesla MRISubfield volumes

Identifiers

PMID42204616
PMCPMC13404107

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.