ArticleBMC complementary medicine and therapies2026
Nanoemulsions of 1,8-cineole, and Eucalyptus globulus and Laurus nobilis essential oils: cytotoxic, antibacterial, and antioxidant activities.
Article in BMC complementary medicine and therapies, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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6 authors.
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Abstract
Antimicrobial and anticancer drug resistance is an increasing concern, driving interest in plant-based nanoformulations. Here, we developed and compared nanoemulsions containing Eucalyptus globulus essential oil (EO), Laurus nobilis EO, and their main constituent, 1,8-cineole. Gas chromatography-mass spectrometry (GC-MS) revealed 1,8-cineole content of 49.5% in E. globulus EO and 37.9% in L. nobilis EO. Nanoemulsions were prepared by spontaneous emulsification and characterized for droplet size (dynamic light scattering) and zeta potential. Attenuated Total Reflectance-Fourier Transform Infrared (ATR-FTIR) spectroscopy qualitatively confirmed EO encapsulation within the nanoemulsions. Average droplet sizes were 172 ± 9 nm (E. globulus EO), 92 ± 5 nm (L. nobilis EO), 137 ± 7 nm (1,8-cineole), and 70 ± 12 nm (blank nanoemulsion). The corresponding zeta potential values were - 24 ± 1.2 mV, - 34 ± 0.7 mV, - 10 ± 0.7 mV, and - 6 ± 1.5 mV. The L. nobilis EO nanoemulsion had the strongest antioxidant activity (IC₅₀ = 342 µg/mL). The E. globulus EO nanoemulsion showed the greatest cytotoxicity against A-375 human melanoma cells (IC₅₀ = 171 µg/mL) and the most potent antibacterial effects against Escherichia coli (IC₅₀ = 762 µg/mL) and Staphylococcus aureus (IC₅₀ = 205 µg/mL). These results suggest that E. globulus EO nanoemulsions have potential as antimicrobial and cytotoxic agents, pending confirmation in in vivo studies.
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