Evidence map›Paper›PMID 42204464›Full record

ArticleBMC plant biology2026

Integrated multi-omics analysis reveals a lipid-redox regulatory network underlying drought tolerance and yield stability in rice.

Rihan Hai, Xi Chen, Yanan Gao, Shan Lu, Xiaojing Wang, Xingjian Xu, Wanda Zhou, Rushun Duan, Guoxin Jiang, Jia Liu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC plant biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Rihan Hai *Key Laboratory of Rice Breeding Innovation in Northern Cold Region in Inner Mongolia, Hinggan League Academy of Agricultural and Animal Husbandry sciences, Ulanhot, 137400, China.
Xi Chen *Key Laboratory of Soybean Molecular Design Breeding, State Key Laboratory of Black Soils Conservation and Utilization, Northeast Institute of Geography and Agroecology, Chinese Academy of Sciences, Harbin, 150000, China.
Yanan GaoKey Laboratory of Soybean Molecular Design Breeding, State Key Laboratory of Black Soils Conservation and Utilization, Northeast Institute of Geography and Agroecology, Chinese Academy of Sciences, Harbin, 150000, China.
Shan LuKey Laboratory of Soybean Molecular Design Breeding, State Key Laboratory of Black Soils Conservation and Utilization, Northeast Institute of Geography and Agroecology, Chinese Academy of Sciences, Harbin, 150000, China.
Xiaojing WangKey Laboratory of Rice Breeding Innovation in Northern Cold Region in Inner Mongolia, Hinggan League Academy of Agricultural and Animal Husbandry sciences, Ulanhot, 137400, China.
Xingjian XuKey Laboratory of Rice Breeding Innovation in Northern Cold Region in Inner Mongolia, Hinggan League Academy of Agricultural and Animal Husbandry sciences, Ulanhot, 137400, China.
Wanda ZhouKey Laboratory of Soybean Molecular Design Breeding, State Key Laboratory of Black Soils Conservation and Utilization, Northeast Institute of Geography and Agroecology, Chinese Academy of Sciences, Harbin, 150000, China.
Rushun DuanJiamusi National Agricultural High Zone, Jiamusi, 156300, China.
Guoxin JiangYazhouwan National Laboratory, Sanya, 572025, China.
Jia LiuKey Laboratory of Soybean Molecular Design Breeding, State Key Laboratory of Black Soils Conservation and Utilization, Northeast Institute of Geography and Agroecology, Chinese Academy of Sciences, Harbin, 150000, China. liujia@iga.ac.cn.

Funding

Central Government-Guided Local Science and Technology Development Fund Projec 2024ZY0006Inner Mongolia Autonomous Region Science and Technology Program 2025KYPT0158Natural Science Foundation of Heilongjiang Province YQ2023C030Youth Innovation Fund Project for Agriculture and Animal Husbandry of Inner Mongolia Autonomous Region 2023QNJJN02
6 · The paper itself

Abstract

backgroundUpland conditions in agroecosystems severely constrain rice productivity. To elucidate the molecular and physiological mechanisms underlying drought tolerance and yield stability in rice, integrated analyses of field phenotyping, transcriptomics, metabolomics, and whole-genome resequencing were conducted using two contrasting rice cultivars, DB46 and LK23.

resultsField evaluations showed that DB46 maintained superior yield stability under upland conditions, which was associated with increased leaf width, whereas LK23 exhibited pronounced leaf rolling that reduced transpiration but severely limited photosynthesis and biomass accumulation. Transcriptomic analyses revealed that DB46 coordinately up-regulated pathways related to fatty acid degradation, α-linolenic acid metabolism, and reactive oxygen species (ROS) detoxification, thereby supporting efficient energy mobilization and redox homeostasis. In contrast, these pathways were broadly suppressed in LK23, resulting in energy deficiency and oxidative stress. Metabolomic profiling further demonstrated significant enrichment of lipid- and secondary metabolism in DB46, including fatty acid biosynthesis, fatty acid metabolism, fatty acid elongation, fatty acid degradation, flavonoid biosynthesis, and phenylalanine metabolism, which collectively contributed to a robust antioxidant defense system. Whole-genome resequencing indicated a more conserved genomic architecture in DB46, whereas LK23 exhibited greater local polymorphism. Integrated multi-omics analyses identified 337 candidate genes associated with lipid metabolism and redox regulation, including lipoxygenase, protein phosphatase 1 L, and PP2C.

conclusionsOur findings uncover a lipid-redox regulatory network that underpins drought tolerance and yield stability in rice. These results provide valuable candidate genes and molecular targets for the genetic improvement and molecular design breeding of drought-resilient rice cultivars.

Indexed as

Lipid MetabolismOryzaDrought ResistanceDroughtsGene Expression ProfilingGene Expression Regulation, PlantMetabolomicsMultiomicsOxidation-ReductionDrought toleranceLipid metabolismMulti-omics analysisRedox homeostasisRice

Identifiers

PMID42204464
PMCPMC13397616

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