Evidence map›Paper›PMID 42204456›Full record

ArticleBMC infectious diseases2026

Helicobacter pylori infection carrying the CagA gene may be associated with the diagnosis and disease progression of tuberculosis.

Fengyan Huang, Hao Zhan, Ying Yang, Liudan Liang, Qiuying Du, Caicun Huang, Jie Huang, Jiannan Lv

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Article in BMC infectious diseases, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Fengyan HuangDepartment of Infection, Affiliated Hospital of Youjiang Medical University for Nationalities, Baise, 533000, China.
Hao ZhanDepartment of Infection, Affiliated Hospital of Youjiang Medical University for Nationalities, Baise, 533000, China.
Ying YangDepartment of Infection, Affiliated Hospital of Youjiang Medical University for Nationalities, Baise, 533000, China.
Liudan LiangDepartment of Infection, Affiliated Hospital of Youjiang Medical University for Nationalities, Baise, 533000, China.
Qiuying DuDepartment of Infection, Affiliated Hospital of Youjiang Medical University for Nationalities, Baise, 533000, China.
Caicun HuangDepartment of Infection, Affiliated Hospital of Youjiang Medical University for Nationalities, Baise, 533000, China.
Jie HuangDepartment of Tuberculosis, HIV/AIDS Clinical Treatment Center of Guangxi (Nanning) and The Fourth People's Hospital of Nanning, Nanning, 530000, China. 229152118@qq.com.
Jiannan LvDepartment of Infection, Affiliated Hospital of Youjiang Medical University for Nationalities, Baise, 533000, China. gxaidscc@163.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

objectiveHelicobacter pylori (H. pylori) infection is associated with infectious diseases caused by pathogens such as Orientia tsutsugamushi (the causative agent of scrub typhus) and Brucella. However, the impact of H. pylori infection on tuberculosis (TB) remains unclear, and in particular, the clinical significance of infection with CagA-positive(CagA

methodsA total of 120 TB patients clinically diagnosed at the Affiliated Hospital of Youjiang Medical University for Nationalities and the Fourth People's Hospital of Nanning from June 2023 to December 2024 were selected as the observation group. The control group consisted of 130 healthy individuals who underwent physical examinations at the same hospitals during the same period, matched by gender, age, and place of residence. The subjects underwent serum H. pylori antibody detection and strain typing using the Western blot method.

result①The H. pylori infection rate was 67.5% in TB patients, slightly higher than 52.3% in healthy individuals, with no statistically significant difference(χ²=1.512, p = 0.219); however, the infection rate of the CagA

conclusionInfection with CagA gene-carrying H. pylori may facilitate the diagnosis of Mycobacterium tuberculosis infection and may influence the disease course of TB.

Indexed as

Antigens, BacterialBacterial ProteinsHelicobacter InfectionsHelicobacter pyloriTuberculosisAdultAgedAntibodies, BacterialCase-Control StudiesDisease ProgressionFemaleHumansMaleMiddle AgedAntibodies, BacterialAntigens, BacterialBacterial ProteinscagA protein, Helicobacter pyloriCagA-positive Helicobacter pyloriHelicobacter pyloriImmunityTuberculosis

Identifiers

PMID42204456
PMCPMC13411762

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