Evidence map›Paper›PMID 42204341›Full record

ArticleScientific reports2026

First evidence for isolation and characterization of Bacopa monnieri (L.) Wettst-derived nanovesicles with anti-neuroblastoma potential.

Ekkaphot Khongkla, Panitch Boonsnongcheep, Pipob Suwanchaikasem, Kornkanok Promthep, Monruedee Srisaisup, Theptharin Charuraksa, Pannaphan Makarathut, Banthit Chetsawang

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Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

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5 · Who and what money

Authors and funding

8 authors.

Ekkaphot KhongklaResearch Center for Neuroscience, Institute of Molecular Biosciences, Mahidol University, Nakhon Pathom, 73170, Thailand. ekkaphot.kho@mahidol.ac.th.
Panitch BoonsnongcheepInstitute of Molecular Biosciences, Mahidol University, Nakhon Pathom, 73170, Thailand.
Pipob SuwanchaikasemBaiya Phytopharm Co., Ltd, Bangkok, 10330, Thailand.
Kornkanok PromthepResearch Center for Neuroscience, Institute of Molecular Biosciences, Mahidol University, Nakhon Pathom, 73170, Thailand.
Monruedee SrisaisupOffice of Research and Innovation Affair, Institute of Molecular Biosciences, Mahidol University, Nakhon Pathom, 73170, Thailand.
Theptharin CharuraksaOffice of Research and Innovation Affair, Institute of Molecular Biosciences, Mahidol University, Nakhon Pathom, 73170, Thailand.
Pannaphan MakarathutOffice of Research and Innovation Affair, Institute of Molecular Biosciences, Mahidol University, Nakhon Pathom, 73170, Thailand.
Banthit ChetsawangResearch Center for Neuroscience, Institute of Molecular Biosciences, Mahidol University, Nakhon Pathom, 73170, Thailand.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Edible plant-derived nanovesicles (PDNVs) have emerged as promising nanotherapeutic strategies for various diseases, including cancer. The biochemical composition and functional properties of PDNVs vary considerably on the basis of their botanical source. Bacopa monnieri (L.) Wettst is a medicinal plant renowned for its rich phytochemical profile, yet the isolation and biological activities of B. monnieri -derived nanovesicles (BMNVs) remain unexplored. We report, for the first time, the isolation, molecular cargo profiling, and in vitro functional evaluation of BMNVs against neuroblastoma cells. The isolated BMNVs displayed a characteristic bilayer morphology with an average particle size of ~ 112 nm. Mass spectrometry-based metabolite analysis revealed that triterpenoids and triterpene saponins are predominant compound classes detected in BMNVs, whereas protein cargo analysis revealed superoxide dismutase, which is correlated with their intrinsic free radical scavenging activities. In vitro assays demonstrated that BMNVs significantly suppress neuroblastoma cell growth and induce morphological alterations. Confocal three-dimensional reconstruction confirmed the cellular internalization of the BMNVs, revealing a distinct perinuclear distribution. This study provides the first evidence of the use of BMNVs as bioactive carriers, highlighting their potential as novel nanotherapeutic agents and establishing B. monnieri as a valuable natural resource for the development of bioactive plant-derived nanovesicles for nanomedicine.

Indexed as

Antineoplastic Agents, PhytogenicBacopaNanoparticlesNeuroblastomaPlant ExtractsCell Line, TumorCell ProliferationHumansSaponinsSuperoxide DismutaseTriterpenesAntineoplastic Agents, PhytogenicPlant ExtractsSaponinsSuperoxide DismutaseTriterpenesBacopa monnieriNanotherapeutic agentNeuroblastomaPlant-derived nanovesiclesSuperoxide dismutaseTriterpenoids

Identifiers

PMID42204341
PMCPMC13443643

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.