Evidence map›Paper›PMID 42204308›Full record

ArticleThe EMBO journal2026

Mitochondrial NADH-redox inflexibility constrains genomic and epigenetic stability in pluripotent stem cells.

Tanveer Ahmed, Hui Zhang, Ghulam M Mushraf, Yongzhang Pan, Zeyu Zhang, Zhenzhu Sun, Mengran Yin, Xueting Xu, Xinyu Wu, Yin Gao and 15 more

Abstract read
In one paragraph

Article in The EMBO journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors.

Tanveer AhmedGuangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences; Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, Guangzhou, 510530, China. tahmed@bs.qau.edu.pk.ORCID http://orcid.org/0000-0003-0519-2315
Hui ZhangGuangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences; Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, Guangzhou, 510530, China.ORCID http://orcid.org/0000-0002-6966-6957
Ghulam M MushrafGuangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences; Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, Guangzhou, 510530, China.ORCID http://orcid.org/0009-0008-0246-3427
Yongzhang PanGuangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences; Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, Guangzhou, 510530, China.ORCID http://orcid.org/0009-0000-8925-2228
Zeyu ZhangGuangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences; Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, Guangzhou, 510530, China.
Zhenzhu SunGuangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences; Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, Guangzhou, 510530, China.ORCID http://orcid.org/0009-0005-0920-782X
Mengran YinGuangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences; Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, Guangzhou, 510530, China.
Xueting XuGuangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences; Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, Guangzhou, 510530, China.
Xinyu WuGuangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences; Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, Guangzhou, 510530, China.ORCID http://orcid.org/0000-0002-5293-5479
Yin GaoGuangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences; Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, Guangzhou, 510530, China.ORCID http://orcid.org/0009-0004-4783-6187
Yan LiGuangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences; Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, Guangzhou, 510530, China.
Peizhi LiGuangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences; Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, Guangzhou, 510530, China.ORCID http://orcid.org/0009-0009-4966-2754
Liang DingGuangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences; Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, Guangzhou, 510530, China.
Qiang ZhangGuangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences; Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, Guangzhou, 510530, China.ORCID http://orcid.org/0009-0006-9138-1989
Runxia LinGuangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences; Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, Guangzhou, 510530, China.
Khair UllahGuangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences; Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, Guangzhou, 510530, China.ORCID http://orcid.org/0009-0005-6812-5955
Yinghua HuangGuangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences; Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, Guangzhou, 510530, China.
Bushra MirzaDepartment of Biochemistry, Quaid-i-Azam University, Islamabad, 45320, Pakistan.
Yifeng HuangGuangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences; Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, Guangzhou, 510530, China.
Abdul SammadGuangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences; Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, Guangzhou, 510530, China.
Xiangqian KongGuangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences; Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, Guangzhou, 510530, China.
Dajiang QinKey Laboratory of Biological Targeting Diagnosis, Therapy and Rehabilitation of Guangdong Higher Education Institutes, The Fifth Affiliated Hospital, Guangzhou Medical University, Guangzhou, 510700, China.
Miguel A EstebanThe Fifth Affiliated Hospital of Guangzhou Medical University-BGI Center for Integrative Biology, The Fifth Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510700, China.
Lulu WangKey Laboratory of Biological Targeting Diagnosis, Therapy and Rehabilitation of Guangdong Higher Education Institutes, The Fifth Affiliated Hospital, Guangzhou Medical University, Guangzhou, 510700, China. wang_lulu@gzhmu.edu.cn.ORCID http://orcid.org/0009-0006-7438-5486
Baoming QinGuangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences; Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, Guangzhou, 510530, China. qin_baoming@gibh.ac.cn.ORCID http://orcid.org/0000-0001-7652-161X

Funding

Bureau of International Cooperation, Chinese Academy of Sciences 2023VBB0006CAS | Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences (GIBH) GIBHBRP23-02GDSTC | Basic and Applied Basic Research Foundation of Guangdong Province () 2022A1515012212GDSTC | Science and Technology Planning Project of Guangdong Province (S&T Project of Guangdong Province) 2023B1212060050MOST | High-end Foreign Experts Recruitment Plan of China () QN2021031005LMOST | National Key Research and Development Program of China (NKPs) 2021YFA1100401MOST | National Key Research and Development Program of China (NKPs) 2025YFC3408900MOST | National Natural Science Foundation of China (NSFC) 32070861MOST | National Natural Science Foundation of China (NSFC) 32100596MOST | National Natural Science Foundation of China (NSFC) 32200650MOST | National Natural Science Foundation of China (NSFC) 32300664MOST | National Natural Science Foundation of China (NSFC) 32370849the National Key R&D Program of China 2025YFC3408900the Shenzhen Medical Research Fund A2504002
6 · The paper itself

Abstract

The electron transport chain (ETC) is essential for NAD

Indexed as

Epigenesis, GeneticGenomic InstabilityMitochondriaNADPluripotent Stem CellsAlcohol OxidoreductasesAnimalsHumansMiceOxidation-ReductionAlcohol OxidoreductasesL-threonine 3-dehydrogenaseNAD

Identifiers

PMID42204308
PMCPMC13324003

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.