Evidence map›Paper›PMID 42204290›Full record

ArticleNature biomedical engineering2026

Cell-based cytokine patch for localized immunomodulation and accelerated healing in rodent and porcine wounds.

Christian C Schreib, Elizabeth L Kelley, Gillian Audia, Raghav Garg, Scott Johnson, Samantha Fleury, Marissa N Behun, Dilrasbonu Vohidova, Mangesh Kulkarni, Grace M Donnell and 4 more

Abstract read
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In one paragraph

Article in Nature biomedical engineering, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Christian C SchreibDepartment of Bioengineering, Rice University, Houston, TX, USA.
Elizabeth L KelleyDepartment of Bioengineering, Rice University, Houston, TX, USA.ORCID http://orcid.org/0009-0007-3642-8614
Gillian AudiaDepartment of Bioengineering, Rice University, Houston, TX, USA.ORCID http://orcid.org/0000-0002-8957-2536
Raghav GargDepartment of Materials Science and Engineering, Carnegie Mellon University, Pittsburgh, PA, USA.ORCID http://orcid.org/0000-0002-3501-6892
Scott JohnsonMcGowan Institute of Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA, USA.
Samantha FleuryDepartment of Bioengineering, Rice University, Houston, TX, USA.ORCID http://orcid.org/0009-0004-5026-1820
Marissa N BehunDepartment of Bioengineering, University of Pittsburgh, Pittsburgh, PA, USA.
Dilrasbonu VohidovaDepartment of Bioengineering, Rice University, Houston, TX, USA.
Mangesh KulkarniDepartment of Bioengineering, University of Pittsburgh, Pittsburgh, PA, USA.
Grace M DonnellDepartment of Bioengineering, Rice University, Houston, TX, USA.
Bryan N BrownDepartment of Bioengineering, University of Pittsburgh, Pittsburgh, PA, USA.
Stephen F BadylakMcGowan Institute of Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA, USA.
Tzahi Cohen-KarniDepartment of Materials Science and Engineering, Carnegie Mellon University, Pittsburgh, PA, USA.
Omid VeisehDepartment of Bioengineering, Rice University, Houston, TX, USA. omid.veiseh@rice.edu.ORCID http://orcid.org/0000-0003-1153-8079

Funding

United States Department of Defense | Defense Advanced Research Projects Agency (DARPA) D20AC00002
6 · The paper itself

Abstract

Wounds can become chronic if the biological processes that coordinate tissue repair, including immune cell activity and matrix remodelling, become dysregulated. Current treatments mainly focus on a wound's physical properties, such as moisture and pressure, and do not restore the disrupted molecular pathways. Here we show a removable patch containing engineered human cells that continuously release native cytokines and that can accelerate healing in rodent and porcine full-thickness wounds. The patch is a polydimethylsiloxane structure that houses alginate-encapsulated human retinal epithelial cells engineered to secrete individual cytokines relevant to tissue repair. Once placed on the wound bed, the cells remain viable and locally release the cytokines over several days. Delivery of interleukin 10, interleukin 12 and transforming growth factor-beta accelerates wound healing in mice and pigs, with accompanying changes in gene expression linked to tissue repair, including pathways involved in skin development and collagen organization. This work suggests that localized, cell-based cytokine delivery may enable future wound treatments that directly modulate the cellular programs governing tissue repair.

Identifiers

PMID42204290

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.