ArticleCommunications medicine2026
Revisiting definitions of hypervirulent and classical Klebsiella pneumoniae through virulence factors and disease phenotype.
Article in Communications medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Molecular Characterization and Clinical Outcomes ofChildren (Basel, Switzerland) · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
Abstract
backgroundHypervirulent Klebsiella pneumoniae (hvKP) has been described as an invasive syndrome of liver abscess and metastatic infection in Asia, and this syndrome is emerging globally.
methodsThis study examined the association between disease phenotypes and genotypic markers of hypervirulence in 273 isolates of Klebsiella pneumoniae (KP) collected from invasive infections across three hospitals in Hong Kong between 2019 and 2023. Whole genome sequencing was analysed by Kleborate and Kaptive. Epidemiological background, disease phenotype, virulence genes, and antimicrobial susceptibility were analysed. Genotypically defined hvKP (g-hvKP) were defined as having iucA, iroB, rmpA, rmpA2, and peg-344. Others were defined as classical Klebsiella pneumoniae (cKP). Genome-wide association study (GWAS) was performed to identify additional genes associated with hvKP.
resultsThe commonest K types are K2 (13.9%) and K1 (10.6%). The commonest ST is ST 23 (8.8%). g-hvKP represents 20.8% of all isolates. The ESBL phenotype is more likely in cKP than g-hvKP (22% vs 9%, p = 0.04). g-hvKP are more susceptible to cephalosporins (p = 0.02) and fluoroquinolones (p = 0.01). Among liver abscess cases, 49% of them are c-KP. g-hvKP is associated with neither mortality, disease severity, nor metastatic infection. g-hvKP has a sensitivity of 46% and a specificity of 86% in detecting liver abscesses or metastatic infections. By omitting rmpA2, F1 score improves from 0.46 to 0.51. GWAS reveals cysH3, pfeA2, and aidA as additional candidate genes linked to hvKP.
conclusionSignificant overlap in disease phenotype exists between cKP and g-hvKP. Additional candidate genes linked to hvKP are cysH3, pfeA2, and aidA.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.