Evaluation of triumeq treatment on a TDP-43 mouse model of amyotrophic Lateral sclerosis.

Megan Fowler, Jillian M Carr, Julian Gold, Adam Walker, Mary-Louise Rogers

Abstract read

In one paragraph

Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Megan FowlerMotor Neuron and Neurotrophic Research Laboratory, College of Medicine and Public Health, Flinders Health and Medical Research Institute, Flinders University, Bedford Park, Adelaide, South Australia, 5042, Australia. megan.fowler@flinders.edu.au.ORCID http://orcid.org/0000-0002-0146-4814

Jillian M CarrVirus Research Laboratory, College of Medicine and Public Health, Flinders Health and Medical Research Institute, Flinders University, Bedford Park, Adelaide, South Australia, 5042, Australia.ORCID http://orcid.org/0000-0002-1080-1472

Julian GoldFaculty of Medicine, Health and Human Sciences, Macquarie University, Sydney, Australia.

Adam WalkerSydney Pharmacy School, Faculty of Medicine and Health, The University of Sydney, Camperdown, NSW, 2006, Australia.ORCID http://orcid.org/0000-0001-7954-5801

Mary-Louise RogersMotor Neuron and Neurotrophic Research Laboratory, College of Medicine and Public Health, Flinders Health and Medical Research Institute, Flinders University, Bedford Park, Adelaide, South Australia, 5042, Australia. louise.rogers@flinders.edu.au.ORCID http://orcid.org/0000-0002-3482-8741

Funding

FightMND DIS-202303-00932Motor Neurone Disease Research Australia IG1950

6 · The paper itself

Abstract

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder characterised by the accumulation of TAR DNA Binding Protein (43 kDa; TDP-43) within the cytoplasm of neurons. Endogenous retroviruses (ERVs) have been implicated in ALS pathology and the application of antiretroviral therapy, specifically Triumeq, has been proposed for treatment of ALS. However, evidence to support the actions of Triumeq in ALS is lacking. This study investigates the effects of the antiretroviral treatment Triumeq on ALS disease that occurs through TDP-43 pathology by utilising the doxycycline (Dox)-suppressible rNLS8 TDP-43 expression mouse model. In this model, TDP-43 accumulation in the cytoplasm is induced after removal of Dox. Disease was assessed through measures of body weight, neurological score, motor function, urinary p75

Indexed as

Amyotrophic Lateral SclerosisDNA-Binding ProteinsAnimalsDisease Models, AnimalMaleMiceMice, TransgenicDNA-Binding ProteinsTardbp protein, mouseAmyotrophic Lateral SclerosisAntiretroviral TherapyEndogenous RetrovirusInflammationNeurodegenerationTDP-43Triumeq

Identifiers

PMID42204279

DOI10.1038/s41598-026-55433-9

PMCPMC13442860

What OpenQuestion holds

Textmetadata

LicenceCC BY-NC-ND

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.