Evidence map›Paper›PMID 42204168›Full record

ArticleNature communications2026

Structural basis of chondroitin sulfate backbone polymer synthesis.

Daniel Tehrani, Nil Cortiella-Valls, Chin Huang, Digantkumar Chapla, Zhifeng Zheng, Aarya Venkat, Brady O'Boyle, Natarajan Kannan, Camilo Perez, Kelley W Moremen

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Daniel Tehrani *Biochemistry and Molecular Biology Department, University of Georgia, Athens, GA, USA.
Nil Cortiella-Valls *Biochemistry and Molecular Biology Department, University of Georgia, Athens, GA, USA.
Chin HuangBiochemistry and Molecular Biology Department, University of Georgia, Athens, GA, USA.ORCID http://orcid.org/0000-0002-4296-0400
Digantkumar ChaplaComplex Carbohydrate Research Center, University of Georgia, Athens, GA, USA.
Zhifeng ZhengComplex Carbohydrate Research Center, University of Georgia, Athens, GA, USA.
Aarya VenkatBiochemistry and Molecular Biology Department, University of Georgia, Athens, GA, USA.ORCID http://orcid.org/0000-0002-8793-4097
Brady O'BoyleBiochemistry and Molecular Biology Department, University of Georgia, Athens, GA, USA.ORCID http://orcid.org/0000-0002-5191-3577
Natarajan KannanBiochemistry and Molecular Biology Department, University of Georgia, Athens, GA, USA.ORCID http://orcid.org/0000-0002-2833-8375
Camilo PerezBiochemistry and Molecular Biology Department, University of Georgia, Athens, GA, USA. camilo.perez@uga.edu.ORCID http://orcid.org/0000-0002-5800-0084
Kelley W MoremenBiochemistry and Molecular Biology Department, University of Georgia, Athens, GA, USA. moremen@uga.edu.ORCID http://orcid.org/0000-0003-1768-582X

Funding

Atlanta Clinical and Translational Science Institute (ACTSI) RenewalUL1TR000454 · NCATS · EMORY UNIVERSITY · PI STEPHENS, DAVID S · 2012 to 2016
$25.8M
TR&D3. Approaches to Proteoglycan Function at Biochemical and Cellular LevelsP41GM103390 · NIGMS · UNIVERSITY OF GEORGIA · PI MOREMEN, KELLEY W. · 2012 to 2019
$14.5M
Origin of N-Glycan Site-Specific HeterogeneityR01GM130915 · NIGMS · UNIVERSITY OF GEORGIA · PI KANNAN, NATARAJAN, MOREMEN, KELLEY W. · 2019 to 2022
$3.4M
Heparan sulfate co-polymerase function and defects in diseaseR01GM154846 · NIGMS · UNIVERSITY OF GEORGIA · PI KELLEY W. MOREMEN · 2024 to 2026
$999k
Molecular mechanism of MFS and MOP lipid transporters in cell wall biosynthesis.R35GM158187 · NIGMS · UNIVERSITY OF GEORGIA · PI Camilo Perez · 2025 to 2026
$756k
NCATS NIH HHS UL1 TR000454NIGMS NIH HHS P41 GM103390NIGMS NIH HHS R01 GM130915NIGMS NIH HHS R01 GM154846NIGMS NIH HHS R35 GM158187U.S. Department of Health & Human Services | National Institutes of Health (NIH) GM103390U.S. Department of Health & Human Services | National Institutes of Health (NIH) GM130915U.S. Department of Health & Human Services | National Institutes of Health (NIH) GM154846U.S. Department of Health & Human Services | National Institutes of Health (NIH) UL1TR000454
6 · The paper itself

Abstract

Chondroitin sulfate (CS) proteoglycans are extended (-GlcAβ1,3GalNAcβ1,4-)

Indexed as

Chondroitin SulfatesAmino Acid SequenceCatalytic DomainCryoelectron MicroscopyModels, MolecularSequence AlignmentChondroitin Sulfates

Identifiers

PMID42204168
PMCPMC13389171

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.