Evidence map›Paper›PMID 42204144›Full record

ArticleNature communications2026

Extensive variation between chromosomes of North American and European hop.

Sandip Mallikarjun Kale, Heidrun Gundlach, Oliver Gericke, Nadia Kamal, Aldo Almeida, Nicholi Pitra, Nicholas Price, Georg Haberer, Thomas Lux, Flavia Krsticevic and 21 more

Abstract read
In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

31 authors.

Sandip Mallikarjun Kale *Carlsberg Research Laboratory, Copenhagen, Denmark.ORCID 0000-0003-0665-5094
Heidrun Gundlach *Helmholtz Munich - German Research Center for Environmental Health, Plant Genome and Systems Biology (PGSB), Neuherberg, Germany.
Oliver Gericke *Carlsberg Research Laboratory, Copenhagen, Denmark.ORCID 0000-0002-8638-6797
Nadia KamalHelmholtz Munich - German Research Center for Environmental Health, Plant Genome and Systems Biology (PGSB), Neuherberg, Germany.ORCID 0000-0002-3258-4130
Aldo AlmeidaCarlsberg Research Laboratory, Copenhagen, Denmark.ORCID 0000-0001-5284-8992
Nicholi PitraHopsteiner, S.S. Steiner, Inc, New York, NY, USA.ORCID 0000-0001-8642-5138
Nicholas PriceHopsteiner, S.S. Steiner, Inc, New York, NY, USA.
Georg HabererHelmholtz Munich - German Research Center for Environmental Health, Plant Genome and Systems Biology (PGSB), Neuherberg, Germany.ORCID 0000-0002-6612-6939
Thomas LuxHelmholtz Munich - German Research Center for Environmental Health, Plant Genome and Systems Biology (PGSB), Neuherberg, Germany.ORCID 0000-0002-5543-1911
Flavia KrsticevicCarlsberg Research Laboratory, Copenhagen, Denmark.
Oliver KempCarlsberg Research Laboratory, Copenhagen, Denmark.ORCID 0009-0002-8911-1200
Louise de BangCarlsberg Research Laboratory, Copenhagen, Denmark.ORCID 0000-0002-6621-8219
Axel HimmelbachLeibniz Institute of Plant Genetics and Crop Plant Research (IPK) Gatersleben, Seeland, Germany.ORCID 0000-0001-7338-0946
Sudharsan PadmarasuLeibniz Institute of Plant Genetics and Crop Plant Research (IPK) Gatersleben, Seeland, Germany.
Mark-Timothy Rabanus-WallaceLeibniz Institute of Plant Genetics and Crop Plant Research (IPK) Gatersleben, Seeland, Germany.ORCID 0000-0002-4663-985X
Lucie HorákováDepartment of Plant Developmental Genetics, Institute of Biophysics of the Czech Academy of Sciences, Brno, Czechia.ORCID 0009-0006-0656-6859
Václav BačovskýDepartment of Plant Developmental Genetics, Institute of Biophysics of the Czech Academy of Sciences, Brno, Czechia.
Kasper NielsenCarlsberg Research Laboratory, Copenhagen, Denmark.ORCID 0000-0002-5510-7767
Nanna BjarnholtDepartment of Plant and Environmental Sciences, Section for Plant Biochemistry, University of Copenhagen, Frederiksberg, Denmark.ORCID 0000-0002-5301-5885
Nikola MicicDepartment of Plant and Environmental Sciences, Section for Plant Biochemistry, University of Copenhagen, Frederiksberg, Denmark.ORCID 0000-0003-3173-6566
Isabella Kruse-AndersenCarlsberg Research Laboratory, Copenhagen, Denmark.ORCID 0009-0009-9546-2147
Birger Lindberg MøllerDepartment of Plant and Environmental Sciences, Section for Plant Biochemistry, University of Copenhagen, Frederiksberg, Denmark.ORCID 0000-0002-3252-3119
Christian JanfeltDepartment of Pharmacy, University of Copenhagen, Copenhagen, Denmark.ORCID 0000-0002-4626-3426
Birgitte SkadhaugeCarlsberg Research Laboratory, Copenhagen, Denmark.ORCID 0000-0001-7317-4376
Paul D MatthewsHopsteiner, S.S. Steiner, Inc, New York, NY, USA.
Klaus F X MayerHelmholtz Munich - German Research Center for Environmental Health, Plant Genome and Systems Biology (PGSB), Neuherberg, Germany.
Nils SteinLeibniz Institute of Plant Genetics and Crop Plant Research (IPK) Gatersleben, Seeland, Germany.ORCID 0000-0003-3011-8731
Martin MascherLeibniz Institute of Plant Genetics and Crop Plant Research (IPK) Gatersleben, Seeland, Germany.ORCID 0000-0001-6373-6013
Manuel SpannaglHelmholtz Munich - German Research Center for Environmental Health, Plant Genome and Systems Biology (PGSB), Neuherberg, Germany. manuel.spannagl@helmholtz-munich.de.ORCID 0000-0003-0701-7035
Alexander FeinerHopsteiner, Simon H. Steiner, Hopfen, GmbH, Mainburg, Germany. alexander.feiner@hopsteiner.de.ORCID 0000-0001-6564-8826
Ilka BraumannCarlsberg Research Laboratory, Copenhagen, Denmark. ilka.braumann@carlsberg.com.ORCID 0000-0002-0617-9465

Funding

Bayerische Forschungsstiftung (Bavarian Research Foundation) ID AZ-1577-22Carlsbergfondet (Carlsberg Foundation) CF14-0214Det Frie Forskningsråd (Danish Council for Independent Research) DFF - 4002-00391Villum Fonden (Villum Foundation) grant no. 19151
6 · The paper itself

Abstract

Hop is an essential ingredient in brewing, providing beer with its characteristic bitterness and aroma. Most modern hop cultivars are hybrids between European and North American hop lineages, but how these ancestries contribute to bitter acid content, the most important trait in hop breeding, remains unclear. Here, we report chromosome-scale, haplotype-resolved assemblies of the hybrid hop cultivar Apollo, assign European and North American ancestry across the genome, and identify varying levels of recombination suppression between chromosomes of either origin. Using this reference, we uncover genetic and chemical diversity in core bittering pathways between European and North American hops. We further show additive effects of beneficial European and North American alleles on bitter acid content, providing a foundation for genomics-assisted hop breeding.

Indexed as

Chromosomes, PlantGenetic VariationHumulusEuropeHaplotypesNorth America

Identifiers

PMID42204144
PMCPMC13216280

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.