ArticleInternational journal of clinical oncology2026
What are the surgical and oncologic outcomes, as well as the complications, associated with pre-operative radiotherapy in patients with low-grade soft-tissue sarcoma?
Article in International journal of clinical oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSurgery with radiotherapy is a standard choice for high-grade soft-tissue sarcoma; however, the indication of radiotherapy for low-grade soft-tissue sarcoma remains controversial due to an inherent low risk of distant metastasis and recurrence after surgery, as well as potential complications after surgery.
methodsBetween 2007 and 2020, a total of 132 patients with low-grade soft-tissue sarcoma treated with pre-operative radiotherapy followed by surgical resection were examined. Pre-operative radiotherapy was administered with 50.4 Gy in 1.8 Gy fractions, with definitive surgery performed 4-8 weeks after completing pre-operative radiotherapy to allow inflammation to subside. Optimal methods for wound closure were performed by plastic surgeons, with the selective use of flap reconstructions (pedicled or free), skin grafts or direct closure.
resultsDiagnoses included well-differentiated liposarcoma/atypical lipomatous tumors (n = 66), myxoid liposarcoma (n = 31), leiomyosarcoma (n = 22), and others. After en-bloc (wide) resections, 78.8% (104/132) underwent plastic reconstruction, including free flaps (51.5%), pedicled flaps (25.8%), and skin grafts (1.5%). The resection margins were R0 in 93.2% (123/132), R1 or R2 in 6.8% (9/132). The 5-year local recurrence-free rate was 99.1%, and distant metastasis-free survival was 90.6%, with nine metastases observed, mainly in myxoid liposarcoma. The disease-specific survival at 5 years was 99.2%. Wound complication-related reoperations occurred in 21.2% (28/132), with similar rates between direct closure (21.4%, 6/28) and plastic reconstruction (21.2%, 22/104, p = 0.705).
conclusionAlthough surgical and oncological outcomes were favourable, the efficacy and invasiveness of pre-operative radiotherapy should be carefully balanced based on the patients' individual background, due to the potential post-operative complications.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.