Evidence map›Paper›PMID 42203970›Full record

ArticleInternational journal of obesity (2005)2026

Gut microbiota alteration contributes to bone marrow mesenchymal stem cells connexin43 response to high-fat diet induced obesity in mice.

Kaiting Ning, Yufei Chen, Xuezhou Yang, Xiangya Dou, Shuaiting Liu, Dong-En Wang, Yinbo Niu, Huiyun Xu

Abstract read
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In one paragraph

Article in International journal of obesity (2005), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Kaiting NingEngineering Research Center of Chinese Ministry of Education for Biological Diagnosis, Treatment and Protection Technology and Equipment, School of Life Science and Technology, Northwestern Polytechnical University, Xi'an, Shaanxi, PR China.
Yufei ChenEngineering Research Center of Chinese Ministry of Education for Biological Diagnosis, Treatment and Protection Technology and Equipment, School of Life Science and Technology, Northwestern Polytechnical University, Xi'an, Shaanxi, PR China.
Xuezhou YangEngineering Research Center of Chinese Ministry of Education for Biological Diagnosis, Treatment and Protection Technology and Equipment, School of Life Science and Technology, Northwestern Polytechnical University, Xi'an, Shaanxi, PR China.
Xiangya DouEngineering Research Center of Chinese Ministry of Education for Biological Diagnosis, Treatment and Protection Technology and Equipment, School of Life Science and Technology, Northwestern Polytechnical University, Xi'an, Shaanxi, PR China.
Shuaiting LiuEngineering Research Center of Chinese Ministry of Education for Biological Diagnosis, Treatment and Protection Technology and Equipment, School of Life Science and Technology, Northwestern Polytechnical University, Xi'an, Shaanxi, PR China.
Dong-En WangEngineering Research Center of Chinese Ministry of Education for Biological Diagnosis, Treatment and Protection Technology and Equipment, School of Life Science and Technology, Northwestern Polytechnical University, Xi'an, Shaanxi, PR China.
Yinbo NiuEngineering Research Center of Chinese Ministry of Education for Biological Diagnosis, Treatment and Protection Technology and Equipment, School of Life Science and Technology, Northwestern Polytechnical University, Xi'an, Shaanxi, PR China. ybniuniu@nwpu.edu.cn.
Huiyun XuEngineering Research Center of Chinese Ministry of Education for Biological Diagnosis, Treatment and Protection Technology and Equipment, School of Life Science and Technology, Northwestern Polytechnical University, Xi'an, Shaanxi, PR China. celldon@nwpu.edu.cn.ORCID http://orcid.org/0000-0002-4873-9934

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND/

objectiveBone marrow mesenchymal stem cells (BMSCs) contribute to controlling adipose tissue homeostasis and may be a potential target for obesity therapy. Since lack of connexin43(Cx43) in mesenchymal stem cells (MSCs) is known to combat high-fat diet (HFD)-induced adiposity. Also, HFD is a well-known risk factor for gut microbiota dysbiosis. Here we attempt to address the interaction between HFD, gut microbiota, and Cx43 deficiency in BMSCs during the development of obesity.

methodsBMSC-specific Cx43 knockout (Prrx1-Cre;Cx43

resultsHFD fed cKO mice notably altered cecal microbiome composition as proved by a distinctively clustered separation from flox mice. Concomitantly, Allobaculum induced by HFD was strongly correlated positively with body weight, glucose intolerance, and adipose mass. The recipients with gut microbiota from cKO mice displayed anti-obesity phenotype as the donors.

conclusionsGut microbiota alteration may be one main reason for the salutary effect of BMSC Cx43 knockout on body adiposity.

Indexed as

Connexin 43Diet, High-FatGastrointestinal MicrobiomeMesenchymal Stem CellsObesityAdipose TissueAnimalsDisease Models, AnimalMaleMiceMice, Inbred C57BLMice, KnockoutConnexin 43

Identifiers

PMID42203970

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.