ArticleAesthetic plastic surgery2026
Comparison of the High-Voltage Electrical Stimulation and Fixed Diphasic Current in Viability of the Transverse Rectus Abdominis Musculocutaneous Flap in Rats Submitted to Nicotine.
Article in Aesthetic plastic surgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Authors and funding
8 authors.
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Abstract
backgroundNicotine compromises tissue perfusion and may reduce the viability of surgical flaps. Electrical stimulation has been investigated as a therapeutic strategy to improve tissue repair and flap survival.
objectiveThe aim of the study was to evaluate and compare the effect of high-voltage electrical stimulation and fixed diphasic current on the viability of the transverse rectus abdominis musculocutaneous flap in rats subjected to the action of nicotine
methodsThirty-six albino Wistar rats were divided into six groups: Saline Group = received saline solution; High-Voltage Electrical Stimulation Group = received saline solution and electrical stimulation with high-voltage current; Fixed Diphasic Current Group = received saline solution and electrical stimulation with fixed diphasic current; Nicotine Group = received nicotine; Nicotine + High-Voltage Electrical Stimulation Group = received nicotine and electrical stimulation with high-voltage current; Nicotine + Fixed Diphasic Current Group = received nicotine and electrical stimulation with fixed diphasic current. The application of high-voltage electrical stimulation or fixed diphasic current occurred immediately after surgery and during the subsequent two days. All groups were submitted to transverse rectus abdominis musculocutaneous flap surgery. The percentage of necrosis was assessed using AxioVision
resultsThe two electric currents were effective in increasing the viability of the transverse rectus abdominis musculocutaneous flap of rats submitted to nicotine. The fixed diphasic current showed better results, with decreased area of necrosis, increased number of mast cells, and increased number of fibroblast growth factor
conclusionsBoth electrical stimulation protocols improved flap viability in rats exposed to nicotine, with fixed diphasic current demonstrating superior effects. NO LEVEL ASSIGNED: This journal requires that authors assign a level of evidence to each submission to which Evidence-Based Medicine rankings are applicable. This excludes Review Articles, Book Reviews, and manuscripts that concern Basic Science, Animal Studies, Cadaver Studies, and Experimental Studies. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266 .
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