Evidence map›Paper›PMID 42203917›Full record

ArticleScientific reports2026

Loganin alleviates oxidative stress-induced apoptosis by modulating mitochondrial function and STAT3 signaling in DSS-induced colitis and H

Guofeng Li, Shuai Zhou, Xing Zhao, Yongfeng Cheng, Zhihua Ma

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Guofeng LiDepartment of Pediatric Intensive Care Unit (PICU), First Affiliated Hospital of Xinjiang Medical University, No. 137, Liyushan Road, Urumqi, 830011, Xinjiang, China.
Shuai ZhouDepartment of Pediatric Intensive Care Unit (PICU), First Affiliated Hospital of Xinjiang Medical University, No. 137, Liyushan Road, Urumqi, 830011, Xinjiang, China.
Xing ZhaoDepartment of Pediatric Intensive Care Unit (PICU), First Affiliated Hospital of Xinjiang Medical University, No. 137, Liyushan Road, Urumqi, 830011, Xinjiang, China.
Yongfeng ChengDepartment of Pediatric Intensive Care Unit (PICU), First Affiliated Hospital of Xinjiang Medical University, No. 137, Liyushan Road, Urumqi, 830011, Xinjiang, China.
Zhihua MaDepartment of Pediatric Intensive Care Unit (PICU), First Affiliated Hospital of Xinjiang Medical University, No. 137, Liyushan Road, Urumqi, 830011, Xinjiang, China. Mazhihua25@163.com.

Funding

Natural Science Foundation of Xinjiang Uygur Autonomous Region 2022D01C217
6 · The paper itself

Abstract

Ulcerative colitis (UC) is a chronic inflammatory bowel disease characterized by recurrent inflammation and mucosal damage. Loganin, a natural iridoid glycoside with anti-inflammatory and antioxidant properties, has shown protective effects in experimental colitis. However, its role in regulating mitochondrial dysfunction, oxidative stress-induced epithelial cell apoptosis, and barrier injury in UC remains incompletely understood. A dextran sulfate sodium (DSS)-induced colitis model was established in mice, and an H

Indexed as

ApoptosisColitisIridoidsMitochondriaOxidative StressSTAT3 Transcription FactorAnimalsCaco-2 CellsDextran SulfateDisease Models, AnimalHumansHydrogen PeroxideIntestinal Barrier FunctionMaleMiceSignal TransductionDextran SulfateHydrogen PeroxideIridoidsloganinSTAT3 Transcription FactorApoptosisLoganinMitochondrial dysfunctionUlcerative colitis

Identifiers

PMID42203917
PMCPMC13447839

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.