ArticleNature2026
αKG-mediated carnitine synthesis drives DNA repair via histone acetylation.
Abstract read
In one paragraph
Article in Nature, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Altered Acylcarnitine Metabolism in cardiac diseases: From molecular mechanisms to translational potential.International journal of cardiology. Heart & vasculature · 2026Review
- Acetyl-CoA-dependent processes are preferentially supported by local metabolite synthesis.Science advances · 2026Article
Corrections and comments
- Update of
Authors and funding
39 authors.
Apoorva UbovejaMolecular and Cellular Oncogenesis Program, The Wistar Institute, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0002-8037-9676
Baixue YangMolecular and Cellular Oncogenesis Program, The Wistar Institute, Philadelphia, PA, USA.
Raquel BujMolecular and Cellular Oncogenesis Program, The Wistar Institute, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0002-8355-6666
Amandine AmalricMolecular and Cellular Oncogenesis Program, The Wistar Institute, Philadelphia, PA, USA.
Hui WangDepartment of Pharmacology & Chemical Biology and UPMC Hillman Cancer Center, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Naveen Kumar TanguduDepartment of Pharmacology & Chemical Biology and UPMC Hillman Cancer Center, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Aidan R ColeMolecular and Cellular Oncogenesis Program, The Wistar Institute, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0001-9647-0848
Julie A DisharoonDepartment of Biochemistry and Molecular Biology, Hollings Cancer Center, Medical University of South Carolina, Charleston, SC, USA.ORCID http://orcid.org/0000-0002-4262-6496
Richard S FangDepartment of Pharmacology & Chemical Biology and UPMC Hillman Cancer Center, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.ORCID http://orcid.org/0009-0001-9559-9735
Evan LevasseurDepartment of Pharmacology & Chemical Biology and UPMC Hillman Cancer Center, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.ORCID http://orcid.org/0009-0008-4698-9551
Miho NaruseMolecular and Cellular Oncogenesis Program, The Wistar Institute, Philadelphia, PA, USA.
Zhentai HuangDepartment of Pharmacology & Chemical Biology and UPMC Hillman Cancer Center, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Emily MegillAging + Cardiovascular Discovery Center, Department of Cardiovascular Sciences, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, USA.
Daniel S KantnerAging + Cardiovascular Discovery Center, Department of Cardiovascular Sciences, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0001-7202-1554
Adam ChatoffAging + Cardiovascular Discovery Center, Department of Cardiovascular Sciences, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0002-7954-9527
Hafsah AhmadAging + Cardiovascular Discovery Center, Department of Cardiovascular Sciences, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, USA.
Mariola M MarcinkiewiczAging + Cardiovascular Discovery Center, Department of Cardiovascular Sciences, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, USA.
Sarah GraffDepartment of Biochemistry, Albert Einstein College of Medicine, Bronx, NY, USA.
Ellen De PieriDepartment of Biochemistry, Albert Einstein College of Medicine, Bronx, NY, USA.
Andrea Andress HuacachinoAging + Cardiovascular Discovery Center, Department of Cardiovascular Sciences, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0002-4084-3411
Frank P VendettiDepartment of Radiation Oncology and UPMC Hillman Cancer Center, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Jeff DanielsonDepartment of Pharmacology & Chemical Biology and UPMC Hillman Cancer Center, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Erika S DahlDepartment of Cellular & Molecular Physiology, Penn State College of Medicine, Hershey, PA, USA.
Jennifer L PenniseAging + Cardiovascular Discovery Center, Department of Cardiovascular Sciences, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, USA.
Esther ElishaevDepartment of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Alison JaccardAging + Cardiovascular Discovery Center, Department of Cardiovascular Sciences, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0002-7737-3118
Lauren BorhoDepartment of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh School of Medicine and Magee-Womens Research Institute, University of Pittsburgh, Pittsburgh, PA, USA.ORCID http://orcid.org/0009-0005-1253-5322
Miriam D PostDepartment of Pathology, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.ORCID http://orcid.org/0000-0001-7220-8247
Kristine CooperBiostatistics Facility, UPMC Hillman Cancer Center, University of Pittsburgh, Pittsburgh, PA, USA.
Francesmary ModugnoDepartment of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh School of Medicine and Magee-Womens Research Institute, University of Pittsburgh, Pittsburgh, PA, USA.
Nadine HempelDepartment of Medicine, Division of Hematology/Oncology and UPMC Hillman Cancer Center, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Wayne StallaertDepartment of Computational & Systems Biology, UPMC Hillman Cancer Center, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Christopher J BakkenistDepartment of Radiation Oncology and UPMC Hillman Cancer Center, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Simone SidoliDepartment of Biochemistry, Albert Einstein College of Medicine, Bronx, NY, USA.ORCID http://orcid.org/0000-0001-9073-6641
Kathryn E WellenDepartment of Cancer Biology, University of Pennsylvania, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0002-2281-0042
Benjamin G BitlerDivision of Reproductive Sciences, Department of Obstetrics and Gynecology, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.ORCID http://orcid.org/0000-0002-5809-5271
David T LongDepartment of Biochemistry and Molecular Biology, Hollings Cancer Center, Medical University of South Carolina, Charleston, SC, USA.ORCID http://orcid.org/0000-0001-9232-0316
Nathaniel W SnyderAging + Cardiovascular Discovery Center, Department of Cardiovascular Sciences, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, USA. NateWSnyder@temple.edu.ORCID http://orcid.org/0000-0001-5643-8747
Katherine M AirdMolecular and Cellular Oncogenesis Program, The Wistar Institute, Philadelphia, PA, USA. kaird@wistar.org.ORCID http://orcid.org/0000-0002-5828-2325
Funding
VECTOR CORE FACILITYP30CA047904 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Jessie Nedrow · 1988 to 2026
$158.0MTumor Microenvironment and MetastasisP30CA010815 · NCI · WISTAR INSTITUTE · PI Nan Zhang · 1985 to 2026
$75.9MProject 3: Hedgehog Inhibition to Enhance Response to ICI TherapyP50CA272218 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Ronald J Buckanovich, Robert Page Edwards · 2023 to 2026
$11.0MIntegrative Cardiovascular PathophysiologyT32HL091804 · NHLBI · TEMPLE UNIV OF THE COMMONWEALTH · PI ELROD, JOHN WILLIAM · 2008 to 2024
$4.5MConnecting BRCA1 functions with DNA crosslink sensitivityR35GM119512 · NIGMS · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI LONG, DAVID THOMAS · 2016 to 2025
$3.9MMetabolic and epigenetic reprogramming in cyclin E high ovarian cancerR01CA259111 · NCI · WISTAR INSTITUTE · PI AIRD, KATHERINE MARIE, SNYDER, NATHANIEL W. · 2021 to 2025
$2.9MInvestigating p16 Loss in Pro-tumorigenic MetabolismR37CA240625 · NCI · WISTAR INSTITUTE · PI AIRD, KATHERINE MARIE · 2020 to 2025
$2.6MPredoctoral Training in Pharmacological Sciences (Resubmission)T32GM133332 · NIGMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Tija C. Jacob, Francisco Jose Schopfer · 2020 to 2026
$1.8MRegulation of mitochondrial redox homeostasis and signaling in metastatic ovarian cancerR01CA242021 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI HEMPEL, NADINE · 2020 to 2024
$1.8MMolecular Biology and Genetics: Signaling, Epigenetics and Genome MaintenanceT32GM142606 · NIGMS · TEMPLE UNIV OF THE COMMONWEALTH · PI Xavier Grana, Kelly A Whelan · 2021 to 2026
$1.5MCell intrinsic and extrinsic effects of zinc metabolism in therapy resistant melanomaR01CA301573 · NCI · WISTAR INSTITUTE · PI Katherine Marie Aird, Raquel Buj Gomez · 2025 to 2026
$1.4MAcylcarnitine Metabolism in Ovarian Cancer ChemoresistanceR01CA298386 · NCI · WISTAR INSTITUTE · PI Katherine Marie Aird, Nathaniel W. Snyder · 2025 to 2026
$1.4MNCI NIH HHS F31 CA236372NCI NIH HHS P30 CA010815NCI NIH HHS P30 CA047904NCI NIH HHS P50 CA272218NCI NIH HHS R01 CA242021NCI NIH HHS R01 CA259111NCI NIH HHS R01 CA298386NCI NIH HHS R01 CA301573NCI NIH HHS R21 CA267050NCI NIH HHS R37 CA240625NHLBI NIH HHS T32 HL091804NIGMS NIH HHS R35 GM119512NIGMS NIH HHS R35 GM156596NIGMS NIH HHS T32 GM133332NIGMS NIH HHS T32 GM142606NIH HHS S10 OD030286
Abstract
Homologous recombination (HR) deficiency increases sensitivity to DNA-damaging agents that are commonly used to treat cancer
Indexed as
CarnitineDNA RepairHistonesKetoglutaric AcidsAcetylationAcetyl Coenzyme AAnimalsCell SurvivalDioxygenasesDNA DamageHomologous RecombinationHumansMixed Function OxygenasesAcetyl Coenzyme ACarnitineDioxygenasesHistonesKetoglutaric AcidsMixed Function Oxygenases
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.