Trial-by-trial auditory brainstem response detection.

George S Liu, Noor-E-Seher Ali, Dáibhid Ó Maoiléidigh

Abstract read

In one paragraph

Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed

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1 · What the graph read from it

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2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

Update of
Trial-By-Trial Auditory Brainstem Response Detection.2026

5 · Who and what money

Authors and funding

3 authors.

George S LiuDepartment of Otolaryngology-Head and Neck Surgery, Stanford University, Stanford, CA, 94304, USA.

Noor-E-Seher AliDepartment of Otolaryngology-Head and Neck Surgery, Stanford University, Stanford, CA, 94304, USA.

Dáibhid Ó MaoiléidighDepartment of Otolaryngology-Head and Neck Surgery, Stanford University, Stanford, CA, 94304, USA. dmelody@stanford.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The neural response of the brainstem to brief sounds, known as the auditory brainstem response (ABR), is widely employed in the laboratory and the clinic to diagnose hearing loss. Current ABR approaches are limited to analyzing the average ABR to hundreds of stimulus trials. Historically, trial-by-trial ABR analysis has not been possible owing to each trial's small signal-to-noise ratio. Here we overcome this limitation and show how to score individual ABR trials. We use the distribution of individual-trial ABR scores to define thresholds, which we call auditory brainstem detection (ABD) thresholds, and to assess suprathreshold hearing. Scores based on individual-trial amplitude and similarity produce lower ABD thresholds than scores based on individual-trial amplitude alone. Our method enables us to rank the suprathreshold hearing of individual subjects. Despite having normal ABR thresholds, some subjects appear to have suprathreshold hearing deficits.

Indexed as

Auditory ThresholdBrain StemEvoked Potentials, Auditory, Brain StemHearing LossAcoustic StimulationAdultAuditory AcuityFemaleHumansMaleSignal-To-Noise RatioAuditory systemEvoked potentialsHearingSignal detectionSuprathresholdThreshold

Identifiers

PMID42203859

DOI10.1038/s41598-026-54233-5

PMCPMC13443214

What OpenQuestion holds

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LicenceCC BY-NC-ND

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.