ArticleNature communications2026
BNT162b2 LP.8.1 early vaccine effectiveness against COVID-19 emergency department, urgent care, and outpatient visits.
Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
COVID-19 continues to cause substantial illness, particularly among older adults and individuals with underlying conditions. Updated vaccines are designed to better protect against the strains of the virus that are currently circulating. However, real-world evidence on the effectiveness of updated vaccines remains limited. Here we show the early vaccine effectiveness (VE) of the BNT162b2 LP.8.1-adapted COVID-19 vaccine against mild-to-moderate COVID-19 outcomes. We used a test-negative case-control design to estimate early VE of the BNT162b2 LP.8.1-adapted vaccine against COVID-19 emergency department/urgent care (ED/UC) and outpatient visits. Adult patients from the US Veterans Affairs Healthcare System with an acute respiratory infection (ARI) who underwent SARS-CoV-2 testing from September 10 to November 30, 2025, were included. VE was estimated using multivariable logistic regression adjusted for patient demographics and clinical characteristics. Among 34,455 ARI episodes, 10.7% were COVID-19 cases. A total of 1.2% of cases and 2.6% of controls received the BNT162b2 LP.8.1 vaccine, with a median time since vaccination of 29 days (interquartile range 20--41). BNT162b2 LP.8.1 vaccine was effective during the early 2025-2026 respiratory virus season. VE was 57% (95% confidence interval [CI] 39-70%) against ED/UC visits and 54% (95% CI 15-75%) against outpatient visits. These findings inform shared decision-making in clinical practice and support the continued importance of COVID-19 vaccination in populations for whom it is recommended.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.