Evidence map›Paper›PMID 42203786›Full record

ArticleNature communications2026

A PI(3,5)P

Tsumugi Shoji, Ayumi Shinojima, Takuma Kishimoto, Kanako Sato, Nana Ikegami, Eisuke Yumoto, Ruri Shindo, Yasunori Uchida, Satoshi Kusumi, Daisuke Koga and 14 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors.

Tsumugi ShojiLaboratory of Organelle Pathophysiology, Department of Integrative Life Sciences, Graduate School of Life Sciences, Tohoku University, Miyagi, Japan.
Ayumi ShinojimaLaboratory of Organelle Pathophysiology, Department of Integrative Life Sciences, Graduate School of Life Sciences, Tohoku University, Miyagi, Japan.
Takuma KishimotoLaboratory of Organelle Pathophysiology, Department of Integrative Life Sciences, Graduate School of Life Sciences, Tohoku University, Miyagi, Japan.
Kanako SatoLaboratory of Organelle Pathophysiology, Department of Integrative Life Sciences, Graduate School of Life Sciences, Tohoku University, Miyagi, Japan.
Nana IkegamiLaboratory of Organelle Pathophysiology, Department of Integrative Life Sciences, Graduate School of Life Sciences, Tohoku University, Miyagi, Japan.
Eisuke YumotoLaboratory of Organelle Pathophysiology, Department of Integrative Life Sciences, Graduate School of Life Sciences, Tohoku University, Miyagi, Japan.
Ruri ShindoLaboratory of Organelle Pathophysiology, Department of Integrative Life Sciences, Graduate School of Life Sciences, Tohoku University, Miyagi, Japan.
Yasunori UchidaLaboratory of Organelle Pathophysiology, Department of Integrative Life Sciences, Graduate School of Life Sciences, Tohoku University, Miyagi, Japan.
Satoshi KusumiDepartment of Morphological Sciences, Kagoshima University, Kagoshima, Japan.
Daisuke KogaDepartment of Microscopic Anatomy and Cell Biology, Asahikawa Medical University, Hokkaido, Japan.ORCID 0000-0002-2792-7207
Eiji YamamotoDepartment of System Design Engineering, Keio University, Kanagawa, Japan.ORCID 0000-0002-8813-5297
Yoshinori HiranoGraduate School of Science and Technology, Keio University, Kanagawa, Japan.ORCID 0000-0001-8219-7991
Ryo OginoDepartment of Pediatrics, Kyoto University Graduate School of Medicine, Kyoto, Japan.ORCID 0009-0004-4265-240X
Hirofumi ShibataDepartment of Pediatrics, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Kazushi IzawaDepartment of Pediatrics, Kyoto University Graduate School of Medicine, Kyoto, Japan.ORCID 0000-0003-1080-0936
Takahiro YasumiDepartment of Pediatrics, Kyoto University Graduate School of Medicine, Kyoto, Japan.ORCID 0000-0003-3257-5071
Ryota SatoSynergy Institute for Futuristic Mucosal Vaccine Research and Development, Chiba University, Chiba, Japan.
Jun NakayamaDepartment of Oncogenesis and Growth Regulation, Research Institute, Osaka International Cancer Institute, Osaka, Japan.ORCID 0000-0001-8844-4295
Shigeki HigashiyamaDepartment of Oncogenesis and Growth Regulation, Research Institute, Osaka International Cancer Institute, Osaka, Japan.
Junya HasegawaGraduate School of Pharmaceutical Sciences, Kitasato University, Tokyo, Japan.ORCID 0000-0003-1216-7468
Hiroaki KajihoMedical Research Laboratory, Institute of Science Tokyo, Tokyo, Japan.ORCID 0000-0001-6376-7629
Takehiko SasakiMedical Research Laboratory, Institute of Science Tokyo, Tokyo, Japan.ORCID 0000-0003-1837-3748
Yoshihiko KuchitsuLaboratory of Organelle Pathophysiology, Department of Integrative Life Sciences, Graduate School of Life Sciences, Tohoku University, Miyagi, Japan. yoshihiko.kuchitsu.d8@tohoku.ac.jp.ORCID 0000-0003-0422-8056
Tomohiko TaguchiLaboratory of Organelle Pathophysiology, Department of Integrative Life Sciences, Graduate School of Life Sciences, Tohoku University, Miyagi, Japan. tomohiko.taguchi.b8@tohoku.ac.jp.ORCID 0000-0003-0464-6370

Funding

MEXT | Japan Society for the Promotion of Science (JSPS) JP24H00548
6 · The paper itself

Abstract

Stimulator of interferon genes (STING) is critical for the type I interferon responses to pathogen- or self-derived cytosolic DNA. STING signalling is terminated by ESCRT-driven lysosomal microautophagy. How STING is directly encapsulated by lysosomes has not yet been understood. Here we show that two lysosomal components, a phosphoinositide PI(3,5)P

Indexed as

Endosomal Sorting Complexes Required for TransportLysosomesMembrane ProteinsPhosphatidylinositol PhosphatesAnimalscGAS-STING Signaling PathwayEndosomesHEK293 CellsHumansMicePhosphatidylinositol 3-KinasesSignal TransductionSTING ProteinEndosomal Sorting Complexes Required for TransportMembrane Proteinsphosphatidylinositol 3,5-diphosphatePhosphatidylinositol 3-KinasesPhosphatidylinositol PhosphatesPikfyve protein, mouseSTING1 protein, humanSTING Protein

Identifiers

PMID42203786
PMCPMC13216264

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.