Evidence map›Paper›PMID 42203543›Full record

ReviewTrends in immunology2026

Human antibodies as emerging drugs for antimicrobial resistance.

Matteo Ridelfi, Vittoria Zucconi Galli Fonseca, Claudia Sala, Rino Rappuoli

Abstract readReview
In one paragraph

Review in Trends in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Matteo RidelfiDepartment of Pediatrics, Center for Vaccine Development and Global Health, University of Maryland School of Medicine, Baltimore, MD, USA.
Vittoria Zucconi Galli FonsecaVaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
Claudia SalaFondazione Biotecnopolo di Siena, Siena, Italy.
Rino RappuoliFondazione Biotecnopolo di Siena, Siena, Italy. Electronic address: rino.rappuoli@biotecnopolo.it.

Funding

Intramural NIH HHS Z99 AI999999
6 · The paper itself

Abstract

Antimicrobial resistance (AMR) is one of today's most worrisome health emergencies. Bacteria, once easily treatable with antibiotics, have acquired resistance to many or all available drugs. In 2019, 1.27 million infection-related deaths were directly caused by AMR. By 2050, AMR could put 10 million lives per year at risk, particularly in low- and middle-income countries. This review focuses on monoclonal antibodies (mAbs) as a novel class of antimicrobials that can bypass classical resistance mechanisms and exert prophylactic and therapeutic effects. The advantages and limitations of mAbs are discussed, along with the need for rapid diagnostics for personalized use. The risk of selecting resistant strains is also addressed, as well as strategies to reduce production costs, expand global access, and improve equity.

Indexed as

antimicrobial resistancemonoclonal antibodiesprecision medicinesuperbugs

Identifiers

PMID42203543
PMCPMC13225620

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.