ArticleThe Journal of veterinary medical science2026
Histopathological analysis of oral epithelial dysplasia in pericancerous epithelium of lingual squamous cell carcinoma of dogs and cats.
Article in The Journal of veterinary medical science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Oral epithelial dysplasia (OED) is a precancerous lesion of oral squamous cell carcinoma (SCC) in humans, characterized by decreased cytokeratin (CK) 13 expression, de novo CK17 expression, and increased Ki-67 expression. This study investigated the histopathological and immunohistochemical features of pericancerous epithelium (PCE) in lingual SCCs of dogs (n=14) and cats (n=8). PCEs were classified as high-grade or low-grade OED based on the human World Health Organization criteria. High-grade OED exhibited decreased CK13 expression, increased CK17 expression, and Ki-67 expression, resembling human high-grade OED. Morphological analysis revealed sharply demarcated lesions with drop-shaped rete processes and irregular epithelial stratification. These findings suggest that OED in canine and feline PCE shares key characteristics with human high-grade OED, supporting the presence of field cancerization in the oral mucosa of domestic animals.
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