Evidence map›Paper›PMID 42203234›Full record

SynthesisEuropean respiratory review : an official journal of the European Respiratory Society2026

Implementation of long-term noninvasive positive airway pressure therapy in patients with COPD: a systematic review and meta-analysis of acceptance and adherence.

Cheryl R Laratta, Linn Moore, Scott W Kirkland, Nana Owusu M Essel, Sandra M Campbell, Rachel Jen, Joanna E MacLean, Sachin R Pendharkar, Brian H Rowe

Abstract readSystematic ReviewMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in European respiratory review : an official journal of the European Respiratory Society, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Cheryl R LarattaDepartment of Medicine, University of Alberta, Edmonton, AB, Canada Cheryl.laratta@ualberta.ca.ORCID https://orcid.org/0000-0002-7656-0173
Linn MooreDepartment of Pediatrics, University of Alberta, Edmonton, AB, Canada.
Scott W KirklandDepartment of Emergency Medicine, University of Alberta, Edmonton, AB, Canada.
Nana Owusu M EsselDepartment of Emergency Medicine, University of Alberta, Edmonton, AB, Canada.
Sandra M CampbellSperber Health Sciences Library, University of Alberta, Edmonton, AB, Canada.
Rachel JenDepartment of Medicine, University of British Columbia, Vancouver, BC, Canada.
Joanna E MacLeanDepartment of Pediatrics, University of Alberta, Edmonton, AB, Canada.ORCID https://orcid.org/0000-0001-7994-9910
Sachin R PendharkarDepartment of Medicine, University of Calgary, Calgary, AB, Canada.ORCID https://orcid.org/0000-0002-4693-0831
Brian H RoweDepartment of Medicine, University of Alberta, Edmonton, AB, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundLong-term noninvasive positive airway pressure (PAP) therapy is an effective, albeit complex, intervention for obstructive sleep apnoea (OSA) and/or chronic hypercapnic respiratory failure (CHRF) in patients with chronic obstructive pulmonary disease (COPD). PAP uptake and use is often reported in studies designed for other purposes. Systematic review methods were used to summarise acceptance of and adherence with PAP therapy.

methodsA systematic search for studies that reported the proportion of patients that either declined or accepted PAP therapy and/or objective use of newly prescribed PAP therapy in patients with COPD was conducted according to a predefined protocol (PROSPERO CRD42021259262). Meta-analysis and meta-regression techniques were used to establish summary effect estimates and explore heterogeneity.

resultsOn average, PAP therapy was declined or discontinued by 14% (95% CI 10-19) of participants, often within 6 weeks of initiation among studies reporting repeated measures. The pooled median adherence was 6.3 h·day

conclusionsAn anticipated six out of seven patients with COPD newly prescribed PAP therapy will be successful using therapy; however, heterogeneity was substantial among studies, and only partly explained by indication for use. Prospective studies to explore barriers to use and detailed reporting of acceptance and adherence in studies on PAP therapy in patients with COPD are needed.

Indexed as

LungPatient Acceptance of Health CarePatient CompliancePulmonary Disease, Chronic ObstructiveSleep Apnea, ObstructiveContinuous Positive Airway PressureFemaleHumansMaleRisk FactorsTime FactorsTreatment Outcome

Identifiers

PMID42203234
PMCPMC13213465

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.