Evidence map›Paper›PMID 42203199›Full record

ArticleJournal of medicinal chemistry2026

Double-Stapled Peptide Scan Yields Potent Fusion Inhibitors of Respiratory Syncytial Virus.

Nadège Pidoux, Logan Roh, Nancy Nicolet, Roger Marti, Adrien Le Rouzic, Clémentine Prompt, Jenna Fix, Stéphane Duquerroy, Félix Rey, Marie-Anne Rameix-Welti and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of medicinal chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Nadège PidouxHES-SO Valais-Wallis, Institute of Life Sciences, HES-SO University of Applied Sciences Western and Arts Switzerland, rue de l'Industrie 19, Sion 1950, Switzerland.
Logan RohHES-SO Valais-Wallis, Institute of Life Sciences, HES-SO University of Applied Sciences Western and Arts Switzerland, rue de l'Industrie 19, Sion 1950, Switzerland.
Nancy NicoletHES-SO Valais-Wallis, Institute of Life Sciences, HES-SO University of Applied Sciences Western and Arts Switzerland, rue de l'Industrie 19, Sion 1950, Switzerland.
Roger MartiInstitute of Chemical Technology, Haute école d'ingénierie et d'architecture Fribourg, HES-SO University of Applied Sciences and Arts Western Switzerland, Fribourg 1700, Switzerland.ORCID 0000-0001-6308-4908
Adrien Le RouzicVIM, INRAE, Domaine de Vilvert, Jouy-en-Josas 78350, France.
Clémentine PromptVIM, INRAE, Domaine de Vilvert, Jouy-en-Josas 78350, France.
Jenna FixVIM, INRAE, Domaine de Vilvert, Jouy-en-Josas 78350, France.
Stéphane DuquerroyUniversité Paris Saclay, Structural Virology Unit, Institut Pasteur, 28 rue du Dr Roux, Paris 75015, France.
Félix ReyUniversité Paris Saclay, Structural Virology Unit, Institut Pasteur, 28 rue du Dr Roux, Paris 75015, France.
Marie-Anne Rameix-WeltiInstitut Pasteur, Université Paris-Saclay, Université de Versailles St. Quentin, Université Paris Cité, Assistance Publique des Hôpitaux de Paris, Hôpital Ambroise Paré, M3P, UMR 1173 (2I), INSERM, Centre National de Référence Virus des Infections Respiratoires (CNR VIR), Paris 75015, France.
Mathilde KeckUniversité Paris-Saclay, CEA, INRAE, Département Médicaments et Technologies pour la Santé (DMTS), SIMoS, Gif-sur-Yvette 91191, France.ORCID 0000-0003-4717-3446
Peggy BarbeUniversité Paris-Saclay, CEA, INRAE, Département Médicaments et Technologies pour la Santé (DMTS), SIMoS, Gif-sur-Yvette 91191, France.
Dominique GarcinDepartment of Microbiology and Molecular Medicine, University of Geneva School of Medicine, CMU, Geneva 1211, Switzerland.
Geneviève Mottet-OsmanDepartment of Microbiology and Molecular Medicine, University of Geneva School of Medicine, CMU, Geneva 1211, Switzerland.
Thibaut LarcherINRAE, Oniris, UMR 703 Apex, Nantes 44307, France.
Marie GallouxVIM, INRAE, Domaine de Vilvert, Jouy-en-Josas 78350, France.
Origène NyanguileHES-SO Valais-Wallis, Institute of Life Sciences, HES-SO University of Applied Sciences Western and Arts Switzerland, rue de l'Industrie 19, Sion 1950, Switzerland.ORCID 0000-0003-1516-1109

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Respiratory syncytial virus infection (RSV) is a major global health concern, particularly in infants and elderly populations. In this work, we have screened and identified 3 double-stapled peptides derived from a minimal domain of the RSV F heptad repeat, namely

Indexed as

Antiviral AgentsPeptidesRespiratory Syncytial VirusesViral Fusion Protein InhibitorsViral Fusion ProteinsAnimalsCrystallography, X-RayFemaleHumansMiceMice, Inbred BALB CModels, MolecularRespiratory Syncytial Virus InfectionsStructure-Activity RelationshipAntiviral AgentsPeptidesViral Fusion Protein InhibitorsViral Fusion Proteins

Identifiers

PMID42203199
PMCPMC13266986

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.