Evidence map›Paper›PMID 42203040›Full record

ArticleJournal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance2026

Measuring atrioventricular valve regurgitation in Fontan patients using cardiovascular magnetic resonance imaging and the association with clinical outcomes: A FORCE Study.

Yu Li, Mary Schiff, Laura J Olivieri, Vivek Muthurangu, Tina Yao, Adam B Christopher, David W Liddle, Victor Morell, Mario Castro-Medina, Mark A Fogel and 5 more

Abstract read
In one paragraph

Article in Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Yu LiDepartment of Pediatrics, UPMC Children's Hospital of Pittsburgh, Pittsburgh, PA, USA.
Mary SchiffDepartment of Pediatrics, Division of Cardiology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA; The Heart Institute, UPMC Children's Hospital of Pittsburgh, Pittsburgh, PA, USA.
Laura J OlivieriDepartment of Pediatrics, Division of Cardiology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA; The Heart Institute, UPMC Children's Hospital of Pittsburgh, Pittsburgh, PA, USA.
Vivek MuthuranguInstitute of Cardiovascular Science, University College London, London, United Kingdom.
Tina YaoInstitute of Cardiovascular Science, University College London, London, United Kingdom.
Adam B ChristopherDepartment of Pediatrics, Division of Cardiology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA; The Heart Institute, UPMC Children's Hospital of Pittsburgh, Pittsburgh, PA, USA.
David W LiddleDepartment of Pediatrics, Division of Cardiology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA; The Heart Institute, UPMC Children's Hospital of Pittsburgh, Pittsburgh, PA, USA.
Victor MorellThe Heart Institute, UPMC Children's Hospital of Pittsburgh, Pittsburgh, PA, USA; Department of Cardiothoracic Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Mario Castro-MedinaThe Heart Institute, UPMC Children's Hospital of Pittsburgh, Pittsburgh, PA, USA; Department of Cardiothoracic Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Mark A FogelDivision of Pediatric Cardiology, Department of Pediatrics, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Yue-Hin LokeDivision of Cardiology, Children's National Hospital, Washington, DC, USA.
Jacqueline KreutzerDepartment of Pediatrics, Division of Cardiology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA; The Heart Institute, UPMC Children's Hospital of Pittsburgh, Pittsburgh, PA, USA.
Rahul H RathodDepartment of Cardiology, Boston Children's Hospital, Boston, MA, USA; Department of Pediatrics, Harvard Medical School, Boston, MA, USA.
Tarek AlsaiedDivision of Pediatric Cardiology, Department of Pediatrics, UT Southwestern Medical Center. Electronic address: Tarek.Alsaied@UTSouthwestern.edu.
FORCE Investigators

Funding

University of Pittsburgh Clinical and Translational Science InstituteUL1TR001857 · NCATS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI REIS, STEVEN E · 2016 to 2025
$129.3M
Institutional Career Development CoreKL2TR001856 · NCATS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI RAY, KRISTIN N, RUBIO, DORIS M · 2016 to 2025
$13.8M
NRSA Training CoreTL1TR001858 · NCATS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI RADOMSKI, THOMAS, RUBIO, DORIS M · 2016 to 2025
$11.1M
Pittsburgh Innovation in Collaborative Training of Residents AllianceR38HL150207 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Charles S Dela Cruz, Corrine R Kliment · 2020 to 2026
$2.1M
NCATS NIH HHS KL2 TR001856NCATS NIH HHS TL1 TR001858NCATS NIH HHS UL1 TR001857NHLBI NIH HHS R38 HL150207
6 · The paper itself

Abstract

backgroundAtrioventricular valve regurgitation (AVVR) predicts long-term post-Fontan adverse outcomes. Literature on the measurement and prognostic value of quantitative AVVR assessment using cardiovascular magnetic resonance imaging (CMR) is limited. This study compared echocardiographic AVVR measurements with measurements by CMR, and investigated their association with clinical outcomes using the multi-center Fontan Outcome Registry using Clinical Examination (FORCE).

methodsPatients with an examiner-reported AVVR severity category from CMR (AVVR

resultsExactly 2309 Fontan patients were included, with a median age at CMR of 15.7 years and (971/2309) 42.1% female. Categorical AVVR severity reported by CMR was significantly associated with adverse outcomes (adjusted HR 2.10, 95% CI [1.38, 3.19] for moderate and 4.61 [2.80, 7.58] for severe AVVR), comparable to AVVR reported by echocardiography. AVVR

conclusionsThis is the first study evaluating different CMR measurements of AVVR in a large cohort of Fontan patients. Compared with AVVR

Indexed as

Atrioventricular valve regurgitationFontanmulticenter studyoutcome researchsingle-ventricle physiology

Identifiers

PMID42203040
PMCPMC13573185

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.