Evidence map›Paper›PMID 42202926›Full record

ArticleInternational journal of biological macromolecules2026

The Diphosphoinositol Polyphosphate Phosphohydrolase 1 family binds IP

David Casas-Flórez, Hayley Whitfield, José M Pérez-Cañadillas, Begoña Monterroso, Andrew M Riley, María A Márquez-Moñino, Megan L Shipton, Julia Sanz-Aparicio, Charles A Brearley, Barry V L Potter and 1 more

Abstract read
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In one paragraph

Article in International journal of biological macromolecules, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

David Casas-FlórezDepartment of Crystallography and Structural Biology, Institute of Physical-Chemistry Blas Cabrera, CSIC, Serrano 119, 28006 Madrid, Spain.
Hayley WhitfieldSchool of Biological Sciences, University of East Anglia, Norwich Research Park, Norwich, NR4 7TJ, UK.
José M Pérez-CañadillasDepartment of Biological Physical Chemistry, Institute of Physical-Chemistry Blas Cabrera, CSIC, Serrano 119, 28006, Madrid, Spain.
Begoña MonterrosoDepartment of Crystallography and Structural Biology, Institute of Physical-Chemistry Blas Cabrera, CSIC, Serrano 119, 28006 Madrid, Spain.
Andrew M RileyDrug Discovery & Medicinal Chemistry, Department of Pharmacology, University of Oxford, Mansfield Road, Oxford, OX1 3QT, UK.
María A Márquez-MoñinoDepartment of Crystallography and Structural Biology, Institute of Physical-Chemistry Blas Cabrera, CSIC, Serrano 119, 28006 Madrid, Spain.
Megan L ShiptonDrug Discovery & Medicinal Chemistry, Department of Pharmacology, University of Oxford, Mansfield Road, Oxford, OX1 3QT, UK.
Julia Sanz-AparicioDepartment of Crystallography and Structural Biology, Institute of Physical-Chemistry Blas Cabrera, CSIC, Serrano 119, 28006 Madrid, Spain.
Charles A BrearleySchool of Biological Sciences, University of East Anglia, Norwich Research Park, Norwich, NR4 7TJ, UK.
Barry V L PotterDrug Discovery & Medicinal Chemistry, Department of Pharmacology, University of Oxford, Mansfield Road, Oxford, OX1 3QT, UK.
Beatriz GonzálezDepartment of Crystallography and Structural Biology, Institute of Physical-Chemistry Blas Cabrera, CSIC, Serrano 119, 28006 Madrid, Spain. Electronic address: xbeatriz@iqf.csic.es.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Diphosphoinositol Polyphosphate Phosphohydrolase 1 (DIPP1) is a Nudix hydrolase involved in inositol pyrophosphate (PP-InsP) metabolism, critical for cellular signaling, energy homeostasis, and stress responses. We report crystallographic and computational studies that reveal 1,5-bis-diphosphoinositol tetrakisphosphate (IP

Indexed as

Acid Anhydride HydrolasesBiocatalysisInositol PhosphatesHumansHydrolysisLigandsModels, MolecularProtein BindingProtein ConformationAcid Anhydride Hydrolasesdiphosphoinositol polyphosphate phosphohydrolaseInositol PhosphatesLigandsDIPP1Inositol polyphosphateinositol pyrophosphateIP(8)Nudix hydrolaseTwist-boat

Identifiers

PMID42202926
PMCPMC7619153

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.