SynthesisJornal de pediatria
Analysis of portal vein thrombosis prevalence and risk factors in neonates following umbilical venous catheterization: a systematic review and meta-analysis.
Synthesis in Jornal de pediatria. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo determine the prevalence of portal vein thrombosis (PVT) in neonates following umbilical venous catheterization (UVC), and to identify risk factors associated with PVT development in this population.
methodsSystematic review conducted in accordance with PRISMA guidelines. Prospective cohort studies assessing PVT in catheterized patients were included. Meta-analyses were performed using random-effects models for prevalence estimates and odds ratios (OR), heterogeneity assessment with Cochran's Q test and Higgins' I², and publication bias with funnel plot and Egger's test.
resultsThe search identified 344 studies, of which 11 met the inclusion criteria. The sample included 1086 neonates (1052 catheterized). Abdominal ultrasound confirmed 200 cases of PVT, yielding a prevalence of 19% (range: 0% to 49%), with six studies reporting prevalence rates above 5%. Meta-analysis showed an association between PVT and blood transfusion or exchange transfusion through the umbilical catheter (p = 0.0024). There was a trend toward increased risk of PVT in neonates with sepsis (p = 0.0705), whereas catheter tip location was not associated with increased PVT prevalence, although there is a risk of bias (p = 0.4636).
conclusionA wide variation in PVT prevalence was observed across the included studies. Blood transfusion through the umbilical catheter was confirmed as a risk factor, while neonatal sepsis was associated with a trend toward this outcome. These findings support the implementation of systematic abdominal ultrasound screening protocols for PVT in all neonates undergoing UVC.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.