Evidence map›Paper›PMID 42202213›Full record

ArticleAmerican journal of respiratory cell and molecular biology2026

Progenitor Resilience and the Early Onset of Chronic Lung Diseases: NHLBI workshop report.

SeungHye Han, Anny Xiaobo Zhou, Amanda M Jamieson, Andrew A Wilson, Bin Zhou, Daniel J Weiss, Dianhua Jiang, Frank McKeon, Harold Chapman, Helen Miranda and 19 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of respiratory cell and molecular biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

29 authors.

SeungHye HanDivision of Pulmonary and Critical Care Medicine, Northwestern University, Chicago, IL, United States.
Anny Xiaobo ZhouDepartment of Medicine, University of Virginia School of Medicine, Charlottesville, VA, United States.
Amanda M JamiesonDepartment of Molecular Microbiology and Immunology, Brown University, Providence, RI, United States.
Andrew A WilsonPulmonary, Allergy, Sleep & Critical Care Medicine, Boston University, Boston, MA.
Bin ZhouCenter for Excellence in Molecular Cell Science, Chinese Academy of Sciences, Shanghai, China.
Daniel J WeissDepartment of Medicine, University of Vermont, Burlington, VT.
Dianhua JiangDepartment of Medicine, Cedars Sinai Medical Center, Los Angeles, CA, United States.
Frank McKeonDepartment of Biology and Biochemistry, University of Houston, Houston, TX.
Harold ChapmanPulmonary and Critical Care Division, University of California, San Francisco, California.
Helen MirandaDepartment of Genetics and Genome Sciences, School of Medicine, Case Western Reserve University, Cleveland, OH.
Herbert B SchillerResearch Unit Precision Regenerative Medicine, Helmholtz Munich, Comprehensive Pneumology Center Munich (CPC-M), Member of the German Center for Lung Research (DZL), Munich, Germany.
Jayaraj RajagopalHarvard Medical School, Massachusetts General Hospital, Boston, MA.
Jeong H YunPulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States.
Jianwen QueDepartment of Medicine, Columbia University, New York, NY.
John F EngelhardtDivision of Pulmonary, Allergy and Critical Care Medicine, University of Alabama at Birmingham, Birmingham, Alabama, 35294.
Maria C BasilDepartment of Medicine, University of Pennsylvania, Philadelphia, PA.
Micha Sam Brickman RaredonDepartment of Anesthesiology, Yale School of Medicine, New Haven, Connecticut.
Mingxia GuDepartment of Anesthesiology & Perioperative Medicine, David Geffen School of Medicine, Broad Stem Cell Research Center, University of California, Los Angeles, Los Angeles, CA, United States.
Moumita GhoshDivision of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, University of Colorado, Anschutz Medical Campus, Aurora, CO, United States.
Preetish Kadur Lakshminarasimha MurthyDepartment of Pharmacology and Regenerative Medicine, University of Illinois Chicago, Chicago, IL, United States.
Purushothama Rao TataDepartment of Cell Biology, Duke University, Durham, NC.
Ruobing WangHarvard Medical School, Boston, MA.
Shawn DavidsonDivision of Pulmonary and Critical Care Medicine, Northwestern University, Chicago, IL, United States.
Susan M MajkaHarvard Medical School, Boston, MA.
Yohannes TesfaigziPulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States.
Christian R GomezDivision of Pulmonary and Critical Care, National Jewish Health, Denver, CO, United States.
Qing LuDivision of Pulmonary and Critical Care, National Jewish Health, Denver, CO, United States.
Jose Ordovas-MontanesDivision of Lung Diseases, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD.
Ravi KalhanDivision of Pulmonary and Critical Care Medicine, Northwestern University, Chicago, IL, United States.

Funding

Mesenchymal Vascular Progenitor Depletion Promotes Lung Aging and Susceptibility to EmphysemaR35HL161238 · NHLBI · NATIONAL JEWISH HEALTH · PI SUSAN M MAJKA · 2022 to 2026
$4.9M
Loss of progenitor function accelerates lung agingR01AG073317 · NIA · NATIONAL JEWISH HEALTH · PI SUSAN M MAJKA, Richard Lee Reinhardt · 2023 to 2026
$2.7M
Regulation of distal basal cells in terminal and respiratory airway regenerationR01HL174610 · NHLBI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI Preetish Kadur Lakshminarasim · 2024 to 2026
$2.1M
Mitochondrial metabolism controls alveolar epithelial cell fateR01HL172859 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Seunghye Han · 2024 to 2026
$1.8M
Disordered mitochondrial proteostasis and alveolar epithelial repair in the aging lungR01HL182777 · NHLBI · NORTHWESTERN UNIVERSITY · PI GR Scott Budinger, NAVDEEP S CHANDEL · 2026 to 2026
$1.6M
NHLBI NIH HHS R01 HL172859NHLBI NIH HHS R01 HL174610NHLBI NIH HHS R01 HL182777NHLBI NIH HHS R35 HL161238NIA NIH HHS R01 AG073317
6 · The paper itself

Abstract

Lung function peaks in young adulthood and declines with age. Studies suggest that this trajectory may be modifiable, potentially enhancing lung health and resilience to prevent or delay the onset of chronic lung disease. Although significant progress has been made in identifying the lung stem/progenitor cell populations involved in lung repair and homeostasis, their regulation and potential for manipulation to promote respiratory health and resilience remain elusive. To explore these issues, the NHLBI organized a virtual workshop on November 7-8, 2024 that aimed to cover the current scientific landscape, address critical research gaps, and identify challenges, opportunities, and key research questions related to chronic lung disease, with a focus on lung stem/progenitor resilience and its applications in the early diagnosis, prevention, and treatment of chronic lung diseases. This report summarizes the scientific presentations, discussions, and recommendations from the workshop.

Identifiers

PMID42202213
PMCPMC13624499

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.