Evidence map›Paper›PMID 42202069›Full record

SynthesisWorld journal of surgery2026

Outcomes After Intraoperative Hypovolemic Phlebotomy in Patients Undergoing Liver Surgery: A Meta-Analysis.

Mohamed Saad Sayed, Nesma Khaled Shalaby, Rahma Mahmoud Almetwaly, Arwa Mohamed Amer Ibrahim, Yusof Mohamed Omar, Ursula Abu Nahla, Ahmed Abokhozima, Hebatullah Abdelazeem

Abstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in World journal of surgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Mohamed Saad SayedFaculty of Medicine, Beni-Suef University, Beni Suef, Egypt.ORCID https://orcid.org/0009-0003-2713-3233
Nesma Khaled ShalabyFaculty of Medicine, Mansoura University, Mansoura, Egypt.
Rahma Mahmoud AlmetwalyFaculty of Medicine, Mansoura University, Mansoura, Egypt.
Arwa Mohamed Amer IbrahimCollege of Medicine, University of Sharjah, Sharjah, UAE.
Yusof Mohamed OmarFaculty of Medicine, Mansoura University, Mansoura, Egypt.
Ursula Abu NahlaFaculty of Medicine, Hebron University, Hebron, Palestine.ORCID https://orcid.org/0009-0001-2356-0751
Ahmed AbokhozimaGeneral Surgery Department, Faculty of Medicine, Alexandria University, Alexandria, Egypt.
Hebatullah AbdelazeemChair of Epidemiology, Department of Health Science, TUM School of Medicine and Health, Technical University of Munich, Munich, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe risk of blood loss in liver surgery remains a recent concern. Recent investigations have shown that intraoperative hypovolemic phlebotomy (HP) is effective at reducing blood loss and transfusions during liver surgery. In this meta-analysis, we seek to assess the effects of HP on patients undergoing liver surgery.

methodsElectronic databases, PubMed, Embase, and Web of Science, were searched from inception to January 2025, with an update in November 2025. Our eligibility criteria included randomized controlled trials (RCTs) or observational studies comparing HP to standard care in patients undergoing liver surgery. A random effects model was used for analysis pooling the mean differences (MD) and risk ratios (RRs) with corresponding 95% confidence intervals (CIs).

resultsA total of 13 studies, with 4577 patients, were analyzed. Compared with the control group, the use of HP was associated with a lower incidence of perioperative RBC transfusion (RR: 0.55, 95% CI: [0.46 to 0.67], p < 0.0001, and I

conclusionAmong patients undergoing liver surgery, the use of HP was associated with a lower blood transfusion rate and blood loss, while maintaining an acceptable safety profile. Further large clinical trials are necessary to clarify the exact mechanism involved.

Indexed as

Blood Loss, SurgicalHepatectomyHypovolemiaIntraoperative CarePhlebotomyErythrocyte TransfusionHumansTreatment Outcomeblood lossblood transfusionsHPhypovolemic phlebotomyliver resectionliver surgeriesliver transplantation

Identifiers

PMID42202069
PMCPMC13356497

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.