Evidence map›Paper›PMID 42202021›Full record

ArticleScience advances2026

A plant immune receptor mediates tritrophic interactions by linking caterpillar detection to predator recruitment.

Natalia Guayazán Palacios, Patrick Grof-Tisza, Brian Behnken, Carla Marques Arce, Di Wu, Antonio F Chaparro, Benjamin D Sheppard, Eric A Schmelz, Ted C J Turlings, Betty Benrey and 1 more

Abstract read
In one paragraph

Article in Science advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Natalia Guayazán PalaciosDepartment of Biology, University of Washington, Seattle, WA, USA.ORCID 0000-0003-3403-6661
Patrick Grof-TiszaLaboratory of Evolutionary Entomology, Institute of Biology, University of Neuchâtel, Neuchâtel, 2000 Switzerland.ORCID 0000-0002-0217-4253
Brian BehnkenDepartment of Biology, University of Washington, Seattle, WA, USA.ORCID 0009-0006-4939-556X
Carla Marques ArceLaboratory of Evolutionary Entomology, Institute of Biology, University of Neuchâtel, Neuchâtel, 2000 Switzerland.ORCID 0000-0002-1713-6970
Di WuDepartment of Biology, University of Washington, Seattle, WA, USA.ORCID 0000-0003-2202-1921
Antonio F ChaparroDepartment of Biology, University of Washington, Seattle, WA, USA.
Benjamin D SheppardDepartment of Biology, University of Washington, Seattle, WA, USA.ORCID 0009-0006-3387-0573
Eric A SchmelzSection of Cell and Developmental Biology, University of California, San Diego, La Jolla, CA, USA.ORCID 0000-0002-2837-734X
Ted C J TurlingsLaboratory of Plant-Insect Research for Sustainable Agriculture (PIRSA), State Key Laboratory of Cotton Bio-breeding and Integrated Utilization, School of Life Sciences, Henan University, Kaifeng 475004, China.ORCID 0000-0002-8315-785X
Betty BenreyLaboratory of Evolutionary Entomology, Institute of Biology, University of Neuchâtel, Neuchâtel, 2000 Switzerland.
Adam D SteinbrennerDepartment of Biology, University of Washington, Seattle, WA, USA.ORCID 0000-0002-7493-678X

Funding

Immunodiversity of plant receptor kinase networks for synthetic circuit designR35GM151272 · NIGMS · UNIVERSITY OF WASHINGTON · PI Adam D Steinbrenner · 2023 to 2026
$1.5M
NIGMS NIH HHS R35 GM151272
6 · The paper itself

Abstract

Plants deploy direct and indirect defenses in response to insect herbivory. The specific antiherbivore responses involve cell surface immune receptors that recognize herbivore-associated molecular patterns (HAMPs), yet the ecological relevance of this molecular interplay in natural settings remains unexplored. Here, we demonstrate with laboratory and field experimentation in Mexico that the inceptin receptor (INR) in the leaves of common bean orchestrates a tritrophic interaction upon recognition of inceptin, a HAMP in caterpillar oral secretions. Near-isogenic lines with a naturally occurring null mutation in INR revealed that inceptin recognition does not only amplify the wound response but activates an herbivore-specific immune pathway to trigger the emission of a distinctive volatile blend that recruits predatory wasps to effectively remove caterpillars from the plants. These findings provide a definitive molecular-to-ecological link, revealing how a single immune receptor mediates ecologically relevant plant-insect-predator interactions in nature.

Indexed as

Plant ProteinsPredatory BehaviorReceptors, ImmunologicAnimalsHerbivoryInnate Immunity RecognitionLarvaPlant LeavesWaspsPlant ProteinsReceptors, Immunologic

Identifiers

PMID42202021
PMCPMC13215194

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.