Evidence map›Paper›PMID 42202003›Full record

ArticleScience advances2026

A miniaturized implantable electrochemical platform for continuous monitoring of metabolites in deep tissue.

Kenneth E Madsen, Dane Hintermueller, Elliot A Opel, Joseph G Ribaudo, Sara Saffari, Soongwon Cho, Joanna L Ciatti, Yu-Ting Huang, Amanda M Westman, Ralph G Nuzzo and 2 more

Abstract read
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In one paragraph

Article in Science advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Kenneth E MadsenQuerrey Simpson Institute for Bioelectronics, Northwestern University, Evanston, IL 60208, USA.ORCID 0000-0002-1336-567X
Dane HintermuellerQuerrey Simpson Institute for Bioelectronics, Northwestern University, Evanston, IL 60208, USA.
Elliot A OpelDepartment of Biomedical Engineering, Northwestern University, Evanston, IL 60208, USA.
Joseph G RibaudoDivision of Plastic and Reconstructive Surgery, Washington University School of Medicine, St Louis, MO 63110, USA.ORCID 0009-0005-9734-3708
Sara SaffariDivision of Plastic and Reconstructive Surgery, Washington University School of Medicine, St Louis, MO 63110, USA.ORCID 0009-0003-3795-2494
Soongwon ChoQuerrey Simpson Institute for Bioelectronics, Northwestern University, Evanston, IL 60208, USA.ORCID 0009-0006-4190-573X
Joanna L CiattiQuerrey Simpson Institute for Bioelectronics, Northwestern University, Evanston, IL 60208, USA.ORCID 0000-0001-5393-522X
Yu-Ting HuangQuerrey Simpson Institute for Bioelectronics, Northwestern University, Evanston, IL 60208, USA.ORCID 0009-0009-1965-3419
Amanda M WestmanDivision of Plastic and Reconstructive Surgery, Washington University School of Medicine, St Louis, MO 63110, USA.ORCID 0000-0002-5436-5481
Ralph G NuzzoDepartment of Chemistry, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.ORCID 0000-0003-2310-2045
Mitchell A PetDivision of Plastic and Reconstructive Surgery, Washington University School of Medicine, St Louis, MO 63110, USA.ORCID 0000-0002-5072-1733
John A RogersQuerrey Simpson Institute for Bioelectronics, Northwestern University, Evanston, IL 60208, USA.ORCID 0000-0002-3830-5980

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The loss or suppression of local metabolic function in living tissues brought about by a lack of oxygen availability (ischemia) serves as the origin for myriad life-threatening conditions including stroke, heart failure, and peripheral ischemic injury. Despite the pressing clinical need to evaluate local tissue health, platforms that support such analysis remain elusive. To address this need, we present a wireless, minimally invasive, multianalyte, electrochemical probe supporting the continuous profiling of local metabolites including K

Indexed as

Electrochemical TechniquesMiniaturizationProstheses and ImplantsAnimalsHumansHydrogen-Ion ConcentrationLactic AcidPotassiumLactic AcidPotassium

Identifiers

PMID42202003
PMCPMC13215199

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.