Evidence map›Paper›PMID 42201876›Full record

ArticlePloS one2026

Why are Massachusetts opioid prescribing rates higher in rural versus urban areas?

Alicia Sasser Modestino, Gary J Young, Md Mahmudul Hasan, Jiesheng Shi, Md Noor E Alam

Abstract read
In one paragraph

Article in PloS one, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

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No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Alicia Sasser ModestinoDepartment of Economics, School of Public Policy and Urban Affairs, Northeastern University, Boston, Massachusetts, United States of America.ORCID https://orcid.org/0000-0001-8998-3282
Gary J YoungStrategic Management and Healthcare Systems, D'Amore McKim School of Business, and Northeastern Center for Health Policy and Healthcare Research, Bouve College of Health Sciences at Northeastern University, Boston, Massachusetts, United States of America.
Md Mahmudul HasanCollege of Pharmacy Department of Information Systems and Operations Management, Warrington College of Business, University of Florida, Gainesville, Florida, United States of America.
Jiesheng ShiDepartment of Mechanical and Industrial Engineering, College of Engineering, Northeastern University, Boston, Massachusetts, United States of America.
Md Noor E AlamMechanical and Industrial Engineering, College of Engineering, Northeastern University, Boston, Massachusetts, United States of America.ORCID https://orcid.org/0000-0001-5353-9710

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimsTo examine the relationship between geographical density and opioid prescribing in a model that simultaneously accounts for both supply and demand side factors.

designUsing the Massachusetts All-Payer Claims (MAPC) Database, we capture individual patient-level characteristics and combine this with county-level data on economic conditions and health care delivery systems to examine the relationship between geographical density and opioid prescribing. POPULATION AND

settingCommercially insured population residing in Massachusetts between 2010 and 2014. METHODOLOGY: Using a logistic regression framework, we determine the likelihood that an individual patient with one of the three conditions (back pain, joint disease, or car accident) will receive an opioid prescription and how this varies by geographic density between patients. We also perform a two-way Blinder-Oaxaca decomposition to understand whether it is the endowments (mean levels) of these factors or the strength of the relationship (coefficients) of those factors that is more important in explaining the differences in opioid prescribing across metropolitan and non-metropolitan areas. Finally, we also explore interactions between the demand and supply side factors.

findingsWe find that patients in non-metropolitan areas were 10 percentage points more likely to receive an opioid prescription. About half of this differential is attributable to the underlying health of the local population. Focusing on three prevalent conditions for which an opioid is commonly prescribed (back pain, joint disease, and car accidents), we find that a little less than half of the remaining gap can be explained by supply side factors, such as differences in the health care delivery system. On the demand side both demographics, particularly veteran status, and health insurance type were important factors. Roughly 80 percent of the difference in opioid prescribing rates can be explained by the inclusion of both sets of covariates. Allowing for the interaction of some demand-side (e.g., working in a physically demanding occupation) and supply-side (e.g., healthcare delivery system) variables further reduces this differential to be less than half of a percentage point and statistically insignificant.

conclusionsOur findings suggest economic conditions, such as the type of working conditions that patients might experience, interact with the healthcare system in unforeseen ways and that more targeted interventions can reduce the persistent gap in opioid prescribing among more and less densely populated areas, with possible downstream impacts on overdose and mortality.

Indexed as

Analgesics, OpioidDrug PrescriptionsPractice Patterns, Physicians'Rural PopulationUrban PopulationBack PainFemaleHumansMaleMassachusettsAnalgesics, Opioid

Identifiers

PMID42201876
PMCPMC13215496

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.