Irinotecan-Loaded Vaterite Microspheres for Drug Delivery: Drug Release and Dissolution Kinetics and Mechanism in an Aqueous Solution and Human Serum.

Morgan P Milner, Hugo A Saint, Jake M Yang, Christopher C M Neumann, Katharina Wansch, Richard G Compton

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Article in Langmuir : the ACS journal of surfaces and colloids, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

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5 · Who and what money

Authors and funding

6 authors.

Morgan P MilnerPhysical and Theoretical Chemistry Laboratory, Department of Chemistry, University of Oxford, Oxford OX1 3QZ, Great Britain.

Hugo A SaintSt John's College, St Giles, Oxford OX1 3JP, Great Britain.

Jake M YangCentre for Sustainable Materials Processing, School of Chemistry, University of Leicester, Leicester LE1 7RH, Great Britain.ORCID 0000-0001-8829-5883

Christopher C M NeumannDepartment of Hematology, Oncology and Tumor Immunology, Charité-Universitätsmedizin Berlin, Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin Institute of Health, Charitéplatz 1, D-10117 Berlin, Germany.

Katharina WanschDepartment of Hematology, Oncology and Tumor Immunology, Charité-Universitätsmedizin Berlin, Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin Institute of Health, Charitéplatz 1, D-10117 Berlin, Germany.

Richard G ComptonPhysical and Theoretical Chemistry Laboratory, Department of Chemistry, University of Oxford, Oxford OX1 3QZ, Great Britain.ORCID 0000-0001-9841-5041

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The coprecipitation synthesis of calcium carbonate vaterite microspheres loaded with chemotherapeutic drug irinotecan is reported. High drug loading comparable to the best reported for other drugs in porous vaterite is achieved, and characterization confirms that the characteristic spherical morphology of vaterite is not disrupted by the presence of irinotecan. UV-vis spectroscopy demonstrates the release of the drug over time, and the latter, upon comparison with optical microscopy dissolution data, shows that drug release correlates with the time scale of dissolution of the vaterite host. To model application in a drug delivery context, the dissolution of unloaded vaterite and irinotecan-loaded vaterite in human serum and diluted human serum is investigated, revealing inhibition of dissolution by human serum that occurs in two distinct serum concentration-dependent ranges. Furthermore, irinotecan-loaded vaterite is tested in vitro on two human pancreatic cancer cell lines, MiaPaCa-2 and Capan-1, demonstrating a therapeutic effect in both cases.

Indexed as

CamptothecinIrinotecanCalcium CarbonateCell Line, TumorDrug Delivery SystemsHumansKineticsSolubilityCalcium CarbonateCamptothecinIrinotecan

Identifiers

PMID42201847

DOI10.1021/acs.langmuir.6c01242

PMCPMC13262042

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