Evidence map›Paper›PMID 42201643›Full record

ArticleLa Radiologia medica2026

Quantification of coronary artery calcium using virtual non-contrast images derived from dual-layer spectral CT.

Ludovica R M Lanzafame, Giorgio Ascenti, Silvio Mazziotti, Agatino Cacciola, Dominika Suchá, Simone Terrani, Niels van Der Werf, Thomas J Vogl, Vitali Koch, Leon D Grünewald and 2 more

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Article in La Radiologia medica, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

12 authors.

Ludovica R M LanzafameDiagnostic and Interventional Radiology Unit, BIOMORF Department, University Hospital "Policlinico G. Martino", Via Consolare Valeria 1, 98100, Messina, Italy.
Giorgio AscentiDiagnostic and Interventional Radiology Unit, BIOMORF Department, University Hospital "Policlinico G. Martino", Via Consolare Valeria 1, 98100, Messina, Italy.
Silvio MazziottiDiagnostic and Interventional Radiology Unit, BIOMORF Department, University Hospital "Policlinico G. Martino", Via Consolare Valeria 1, 98100, Messina, Italy.
Agatino CacciolaDiagnostic and Interventional Radiology Unit, BIOMORF Department, University Hospital "Policlinico G. Martino", Via Consolare Valeria 1, 98100, Messina, Italy.
Dominika SucháDepartment of Radiology and Nuclear Medicine, University Medical Center Utrecht, Heidelberglaan 100, 3584, Utrecht, The Netherlands.
Simone TerraniClinical Application Department, Philips Healthcare, Viale Sacra 235, 20126, Milan, Italy.
Niels van Der WerfPhilips Healthcare, Best, The Netherlands.
Thomas J VoglDepartment of Diagnostic and Interventional Radiology, University Hospital Frankfurt, Theodor-Stern-Kai 7, 60590, Frankfurt Am Main, Germany.
Vitali KochDepartment of Diagnostic and Interventional Radiology, University Hospital Frankfurt, Theodor-Stern-Kai 7, 60590, Frankfurt Am Main, Germany.
Leon D GrünewaldDepartment of Diagnostic and Interventional Radiology, University Hospital Frankfurt, Theodor-Stern-Kai 7, 60590, Frankfurt Am Main, Germany.
Christian BoozDepartment of Diagnostic and Interventional Radiology, University Hospital Frankfurt, Theodor-Stern-Kai 7, 60590, Frankfurt Am Main, Germany.
Tommaso D'AngeloDiagnostic and Interventional Radiology Unit, BIOMORF Department, University Hospital "Policlinico G. Martino", Via Consolare Valeria 1, 98100, Messina, Italy. tommasodang@gmail.com.ORCID http://orcid.org/0000-0003-0004-6378

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo evaluate the feasibility of deriving coronary artery calcium (CAC) scores from Virtual-Non-Contrast (VNC) reconstructions obtained with dual-layer computed tomography (DLCT).

methodsA retrospective study was conducted on 100 patients who underwent coronary computed tomography angiography (CCTA) with a DLCT scanner. Conventional true non-contrast (TNC) images were reconstructed for CAC quantification (CAC

resultsThe median CAC

conclusionsVNC reconstructions from DLCT show excellent correlation and good agreement with conventional TNC images for CAC quantification. This approach has the potential to eliminate the need for a dedicated unenhanced scan, thereby reducing radiation exposure, and acquisition time while preserving diagnostic accuracy.

Indexed as

Computed Tomography AngiographyCoronary AngiographyCoronary Artery DiseaseVascular CalcificationAgedFeasibility StudiesFemaleHumansMaleMiddle AgedRadiographic Image Interpretation, Computer-AssistedRetrospective StudiesComputed tomography angiographyCoronary artery diseaseDual energy computed tomographyVascular calcificationVirtual non-contrast

Identifiers

PMID42201643

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.