ArticleRheumatology and therapy2026
Clinical and Economic Burden Among People with Knee Osteoarthritis and Obesity in the United States: A Retrospective Analysis.
Article in Rheumatology and therapy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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9 authors.
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Abstract
introductionObesity and knee osteoarthritis (KOA) are prevalent conditions that significantly impact public health and healthcare costs. We aimed to quantify the economic burden and explore the relationship between obesity and KOA pain.
methodsThis study used Optum's de-identified Market Clarity Data from October 1, 2015, to March 31, 2024. Adults (≥ 45 years) with moderate-to-severe osteoarthritis (MTS-OA) knee pain (index date: first-observed claim with a KOA diagnosis between October 1, 2016, and March 31, 2023), with continuous enrollment in commercial, Medicare, or Medicaid healthcare plans for 1 year before and after post index, were included. The presence of KOA pain was identified using a previously validated algorithm. Adjusted annualized all-cause and KOA-related healthcare resource utilization and costs were assessed in the first year after index date, stratified by body mass index (BMI) categories: normal (≥ 18.5 to < 25 kg/m
resultsThe prevalence of obesity-related complications was high, particularly among those with a BMI ≥ 35 kg/m
conclusionsIn people with MTS-OA knee pain, this descriptive analysis revealed higher observed average overall and disease-specific healthcare expenditure in Class 2 and 3 obesity than in other BMI categories.
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