Effect of combination of osteoblasts and octacalcium phosphate collagen composite on bone regeneration in rat calvarial bone defect.

Hiroshi Kato, Satoki Nishimura, Shoko Onodera, Akira Watanabe

Abstract read

In one paragraph

Article in Medical molecular morphology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

4 authors.

Hiroshi KatoDepartment of Oral and Maxillofacial Surgery, Tokyo Dental College, 2-9-18 Kanda Misakicho, Chiyoda-Ku, Tokyo, 100-0061, Japan. katohiroshi@tdc.ac.jp.ORCID http://orcid.org/0000-0002-8756-6925

Satoki NishimuraDepartment of Oral and Maxillofacial Surgery, Tokyo Dental College, 2-9-18 Kanda Misakicho, Chiyoda-Ku, Tokyo, 100-0061, Japan.

Shoko OnoderaDepartment of Biochemistry, Tokyo Dental College, Tokyo, Japan.

Akira WatanabeDepartment of Oral and Maxillofacial Surgery, Tokyo Dental College, 2-9-18 Kanda Misakicho, Chiyoda-Ku, Tokyo, 100-0061, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study aimed to assess the effect of a combination of osteoblasts and octacalcium phosphate collagen composite (OCP/Col) on bone regeneration. In oral and maxillofacial surgery, OCP/Col has been clinically used as artificial bone. Although OCP/Col was reported to promote osteoblast differentiation, few studies have reported on its use in combination with cell transplantation. Moreover, its effects are not fully clarified. Therefore, we evaluated the osteogenic properties of a combination of OCP/Col and osteoblasts. We found that osteoblasts cultured in OCP/Col differentiated toward osteolineage, expressing several osteoblast markers. In animal experiments, the cell transplantation group showed promotion of osteoblast differentiation and stromal formation in the tissues compared with the OCP/Col group. These findings indicate that combining osteoblasts and OCP/Col would be beneficial for bone regeneration therapy.

Indexed as

Bone RegenerationCalcium PhosphatesCollagenOsteoblastsSkullAnimalsCell DifferentiationCells, CulturedMaleOsteogenesisRatsCalcium PhosphatesCollagenoctacalcium phosphateArtificial boneBone regenerationCell transplantationOctacalcium phosphateOsteoblast

Identifiers

PMID42201551

DOI10.3390/ijms20246123

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.