ReviewMolecular biology reports2026
The role of the cGAS-STING pathway in male reproductive disorders.
Review in Molecular biology reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
3 authors.
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Abstract
Recently, the cGAS-STING signaling pathway has garnered significant attention due to its role in the pathogenesis of various disorders, including cancer, autoimmune diseases, and auto-inflammatory diseases. This pathway is a novel innate immune recognition mechanism that functions as a cytoplasmic DNA sensor. It mediates protective immune responses against tumor-derived DNA, DNA-containing pathogens, and cytoplasmic DNA (nuclear and mitochondrial DNA) by producing a range of inflammatory cytokines. Although the normal activation of cGAS-STING signaling induces innate immunity against infections, aberrant activation of the cGAS-STING axis is associated with excessive inflammatory responses, leading to an immune system attack on normal tissues and contributing to the development of autoimmune diseases. Activation of the cGAS-STING also emerges as a double-edged sword in different types of cancer. There are different perspectives on the abnormal function of the cGAS-STING pathway in various male reproductive disorders. Understanding the factors that regulate the cGAS-STING pathway and its involvement in male reproductive system issues can help develop new strategies for prevention and treatment. This review focuses on the role of the cGAS-STING signaling pathway in male reproductive-related diseases. We also explore targeting the cGAS-STING signaling pathway for the prevention and treatment of male reproductive diseases.
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